载药静电纺丝纤维研究及应用进展

ADVANCES IN THE RESEARCH AND APPLICATION OF DRUG-LOADED ELECTROSPINNING NANOFIBERS

随着科学技术和医学研究的进步,纳米材料在药物载体中发挥着越来越重要的作用。静电纺丝技术为生产纳米纤维最常用的技术之一,静电纺丝纤维因具有比表面积大、孔隙率高等优点,得到研究者的广泛关注。在生物医学领域,多种材料和技术方法被用于制备静电纺丝纤维,可实现理想包封和负载多种药物,通过调整支架对药物的释放,发挥良好的抗癌、抗感染以及诱导细胞分化等作用。本文就载药静电纺丝纤维的研究及应用进展作一综述。

With the development of science and medical research,nanomaterials play an increasingly important role in drug delivery.The electrospinning technique is one of the most commonly used methods for fabricating nanofibers,and electrospinning nanofibers have attracted wide attention due to the advantages such as large specific surface area and high porosity.In the field of biomedicine,various materials and techniques have been used to fabricate electrospinning fibers and can help to achieve ideal encapsulation and the loading of multiple drugs,and the release of drug through stents is adjusted to exert good antitumor and anti-infective effects and play a role in inducing cell differentiation.This article reviews the recent advances in the research and application of drug-loaded electrospinning nanofibers.