穴位贴敷联合清感颗粒治疗急性病毒性上呼吸道感染外感风热证的临床疗效观察

Clinical efficacy on acupoint patching combined with Qinggan granule for acute viral upper respiratory tract infection of exogenous wind-heat syndrome

目的观察穴位贴敷联合清感颗粒治疗急性病毒性上呼吸道感染外感风热证的临床疗效。方法将238例(后脱落8例)急性病毒性上呼吸道感染外感风热证患者按照随机数字表法分为3组,西药组78例采用西药治疗,中药组75例采用口服清感颗粒治疗,中药+贴敷组77例采用清感颗粒联合穴位贴敷治疗。3组均治疗72 h。比较3组治疗前后体温、咽痛、头痛缓解情况。结果3组治疗后1、2、3、4、12 h体温呈下降趋势(P<0.05)。与本组治疗前比较,西药组、中药+贴敷组在治疗后1 h均降低(P<0.05),3组治疗后2、3、4、12 h体温均降低(P<0.05)。中药组、中药+贴敷组治疗后1、2、3、4 h体温下降≥0.5℃例数呈递增趋势(P<0.05),且中药+贴敷组优于中药组(P<0.05)。中药组治疗后48、72 h体温正常比率均高于西药组(P<0.05),中药+贴敷组治疗后24、48、72 h体温正常比率均高于西药组(P<0.05)。3组咽痛总有效率比较差异无统计学意义(P>0.05)。中药组头痛改善总有效率95.83%(69/72),中药+贴敷组头痛改善总有效率94.74%(72/76),均高于西药组的89.33%(67/75)(P<0.05)。中药组不良反应发生率6.67%(5/75)、中药+贴敷组不良反应发生率9.09%(7/77),均低于西药组的19.23%(15/78)(P<0.05)。结论中药组、中药+贴敷组治疗急性病毒性上呼吸道感染退热疗效确切,且可维持体温72 h正常率较高,中药+贴敷组1 h退热效果明显。

Objective To observe clinical efficacy on acupoint patching combined with Qinggan granule for acute viral upper respiratory tract infection(exogenous wind-heat syndrome).Methods Totally 238 patients(8 cases of shedding)with acute viral upper respiratory tract infection(exogenous wind-heat syndrome)were randomly assigned to receive Western medicine(WM group,n=78),oral Qinggan granule(traditional Chinese medicine[TCM]group,n=75)or acupoint patching+Qinggan granule(combination group,n=77).Treated for 72 h,the aim was to compare body temperature,the remission rates of pharyngalgia and headache.Results The 1-h,2-h,3-h,4-h,12-h body temperature in the three groups showed a decreasing trend(P<0.05).Compared with before treatment,the 1-h body temperature in WM group and combination group was decreased(P<0.05),the 2-h,3-h,4-h,12-h body temperature in the three groups were decreased(P<0.01).The 1-h,2-h,3-h,4-h proportion of cases with body temperature≥0.5℃in TCM group and combination group were gradually increased(P<0.05),which were better in combination group than in TCM group(P<0.05).Compared with WM group,the 48-h,72-h recovery rate of body temperature in TCM group were higher(P<0.05),the 24-h,48-h,72-h recovery rate of body temperature in combination group were higher(P<0.05).The difference was not statistically significant in the overall effective rate of pharyngalgia among groups(P>0.05).The overall effective rate of headache improvement in TCM group and combination group was better than that in WM group(95.83%[69/72],94.74%[72/76]vs 89.33%[67/75],[P<0.05],respectively).The incidence of adverse reactions in TCM group,combination group was lower than that in WM group(6.67%[5/75]vs 9.09%[7/77]vs 19.23%[15/78],[P<0.05],respectively).Conclusion TCM group and combination group have definite curative effect on reducing fever,with higher 72-h normal temperature rate;meanwhile,the combination group has significant antipyretic effects.