清胰汤治疗急性胰腺炎临床疗效和对炎症因子水平的影响研究

Clinical efficacy of Qingyi Decoction for acute pancreatitis and its influence on inflammatory factors

目的观察清胰汤治疗急性胰腺炎(AP)的临床疗效。方法将89例AP患者按照随机数字表法分为2组,对照组44例予常规西医治疗,治疗组45例在对照组治疗基础上加用清胰汤治疗1~2周。比较2组治疗前后血清白细胞介素6(IL-6)、IL-8、肿瘤坏死因子α(TNF-α)、核转录因子κB(NF-κB)水平,监测血清C反应蛋白(CRP)、淀粉酶(AMY)、白细胞计数(WBC)降至正常所需要的天数;记录住院中是否存在肠梗阻、禁食天数和住院天数,并评估临床疗效。结果治疗组住院过程中肠梗阻发生率、住院天数及禁食天数均低于对照组(P<0.05)。治疗组CRP、WBC降至正常的天数均低于对照组(P<0.05),2组AMY降至正常的天数比较差异无统计学意义(P>0.05)。2组治疗后IL-6、TNF-α、IL-8、NF-κB水平均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。治疗组总有效率93.33%(42/45),对照组总有效率90.91%(40/44),治疗组疗效优于对照组(P<0.05)。结论清胰汤治疗急性胰腺炎疗效确切,其可能是通过降低机体的炎性反应以提高临床疗效。

Objective To observe the clinical efficacy of Qingyi Decoction for acute pancreatitis(AP).Methods A total of 89 AP patients were randomly assigned to the treatment group(n=45)and the control group(n=44).All patients were managed by routine Western medicine,and those in the treatment group were additionally treated with Qingyi Decoction for 1-2 weeks.The changes in interleukine-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α),nuclear factor Kappa B(NF-κB),C-reactive protein(CRP),amylase(AMY)and white blood cell count(WBC)were recorded,the incidence of intestinal obstruction during hospitalization,duration of fasting and hospitalization were compared.Results The incidence of intestinal obstruction,duration of fasting and hospitalization were lower in the treatment group than in the control group(P<0.05).The days to decreased to normal level of CRP and WBC in the treatment group was shorter than those in the control group(P<0.05).Difference in the days to decreased to normal level of AMY was not significant between groups(P>0.05).IL-6,TNF-α,IL-8,NF-κB in groups were decreased(P<0.05),improvement of which in the treatment group were significantly better(P<0.05).The overall effective rate was 93.33%(42/45)in the treatment group,higher than that of 90.91%(40/44)in the control group(P<0.05).Conclusion Qingyi Decoction may improve clinical effect by reducing the body inflammatory response.