脊髓小脑共济失调非运动症状研究现状

Research Status of Non-motor Symptoms of Spinocerebellar Ataxia

脊髓小脑性共济失调(SCAs)是一组以晚发型共济失调等多种表现为特征的常染色体显性遗传性神经退行性疾病,进行性共济失调是其典型的临床特征,可导致严重残疾和过早死亡。SCAs的共济失调等运动症状已得到神经专科医生的广泛关注。然而,SCAs的非运动症状常被忽视。文中描述了SCAs患者的部分较常见非运动症状特征,以及对SCAs患者生活质量的影响。通过了解这些非运动症状,希冀提高对SCAs的认识和诊疗水平。

Spinocerebellar ataxias(SCAs)is a group of autosomal dominant neurodegenerative diseases characterized by multiple manifestations such as late-onset ataxia.Its typical clinical feature is progressive ataxia,which can lead to severe disability and premature death.Motor symptoms such as ataxia have been widely concerned by neurologists,but the non-motor symptoms of SCAs are often ignored.Some common characteristics of non-motor symptoms and their impact on the quality of life in patients with SCAs were described and discussed to improve the understanding and diagnosis of the disease.