颈动脉斑块内新生血管与缺血性脑卒中发生的研究进展

Relationship between Neovascularization in Carotid Plaque and Ischemic Stroke

斑块内出血是心脑血管事件发生的危险因素,斑块新生血管是斑块生长和不稳定的重要因素。血管不成熟、结构和功能严重异常导致斑块内反复出血。随着影像学技术的发展斑块内血管生成状况能够被更好的检测到,对监测动脉粥样硬化的发展、动脉斑块的稳定性以及缺血性脑卒中的预防具有重要临床意义。文中从斑块内血管的生成机制、血管生成与缺血脑性卒中的关系以及检测血管生成的影像学方法进行综述。

Intraplaque hemorrhage is a risk factor for cardiovascular and cerebrovascular events,and plaque angiogenesis is an important factor for plaque growth and instability.Immature blood vessels with severe structural and functional abnormalities lead to repeated bleeding within the plaque.Plaque angiogenesis can be better measured with the development of imaging.It has important clinical significance for monitoring the development of atherosclerosis,the stability of arterial plaque and the prevention of ischemic stroke.Therefore,the mechanism of angiogenesis in carotid plaque,the relationship between angiogenesis and ischemic stroke,and the imaging methods for detecting angiogenesis were reviewed.