阿尔茨海默病中精神行为症状的研究进展

Recent advances in behavioral and psychological symptoms of Alzheimer's disease

作为痴呆中最常见的一种类型,90%的阿尔茨海默病(AD)患者会表现出痴呆的精神行为症状(BPSD)。BPSD常导致AD患者预后不良和功能障碍,但目前鲜有安全有效的治疗方法。笔者现概述AD中不同BPSD表现的发生频率及其随临床病程进展的变化,并重点介绍目前关于AD中BPSD的遗传学特点、病理生理机制、生物标志物、治疗手段等方面的研究进展,以期为AD中BPSD的早期识别与治疗提供参考。

Behavioral and psychological symptoms of dementia(BPSD)is a common symptom of Alzheimer's disease(AD),with an occurrence of 90%.BPSD can lead to poor prognosis and dysfunction in patients with AD,but few safe and effective treatments are available.This article overviews the occurrence frequencies of different manifestations of BPSD in AD and their changes with clinical courses of the disease,and introduces the current research progress on genetic characteristics,pathophysiological mechanism,biomarkers and therapeutics of BPSD in AD to provide references for early recognition and treatment of BPSD in AD.