紫艾鼻通膏佐治小儿变应性鼻炎风痰束窍证38例临床观察

Clinical observation on 38 cases of allergic rhinitis in children with wind phlegm restricting orifices syndrome treated by Ziai Bitong Gao(紫艾鼻通膏) as adjuvant therapy

目的观察紫艾鼻通膏佐治小儿变应性鼻炎风痰束窍证的临床疗效。方法选取2020年8月至2021年11月在无锡市中医医院儿科门诊就诊的变应性鼻炎风痰束窍证患儿76例,按照随机数字表法分为对照组和治疗组,各38例。对照组予氯雷他定、孟鲁司特钠咀嚼片口服,治疗组在对照组治疗方法的基础上予自制中药紫艾鼻通膏涂鼻腔,2组均治疗4周后统计疗效。结果治疗前2组中医证候积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组喷嚏、清水样涕、鼻痒、鼻塞中医证候积分均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。对照组总有效率为73.68%(28/38),治疗组为92.11%(35/38),2组比较,差异有统计学意义(P<0.05)。对照组总不良反应发生率为10.52%(4/38),治疗组为5.26%(2/38),2组比较,差异有统计学意义(P<0.05)。结论紫艾鼻通膏佐治小儿变应性鼻炎风痰束窍证,能明显缓解患儿的临床症状、体征,疗效确切,且不良反应小,值得临床推广应用。

Objective To observe the clinical efficacy of allergic rhinitis in children with wind phlegm restricting orifices syndrome treated by Ziai Bitong Gao(紫艾鼻通膏) as adjuvant therapy.Methods 76 cases of allergic rhinitis in children with wind phlegm restricting orifices syndrome treated in the pediatric outpatient department of Wuxi Hospital of Traditional Chinese Medicine from August 2020 to November 2021 were divided into a control group and a treatment group in a random number table,with 38 cases in each group.The control group was given loratadine and Montelukast sodium chewable tablets orally. On the basis of the treatment of the control group,the treatment group was added with self-made traditional Chinese medicine Ziai Bitong Gao to smear the nasal cavity.We kept statistics about the efficacy after the 2 groups were both treated for 4 weeks.Results Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05), which was comparable.After treatment,TCM syndrome scores for sneezing, runny nose, Hchy nose and staffy nose of the 2 groups were significantly decreased,compared with those of the same group before treatment, the differences were statistically significant (P<0.05),and the decrease was more significant in the treatment group(P<0.05). The total effective rate of the control group was 73.68%(28/38),and that of the treatment group was 92.11%(35/38).The difference between the two groups was statistically significant (P<0.05).The total incidence of adverse reactions was 10.52%(4/38) in the control group and 5.26%(2/38) in the treatment group.The difference between the two groups was statistically significant (P<0.05).Conclusion It can markedly relieve the clinical symptoms and signs of patients to use self-made Ziai Bitong Gao as adjuvant therapy for allergic rhinitis in children with wind phlegm restricting orifices syndrome,with marked curative effect,small adverse reactions,which deserves clinical promotion and application.