1990-2019年中国心房颤动和心房扑动疾病负担及危险因素变化情况的分析

Analysis of changes in disease burden and risk factors of atrial fibrillation and atrial flutter in China from 1990 to 2019

目的系统分析1990—2019年中国心房颤动和心房扑动疾病负担及危险因素的变化情况,为疾病的治疗和管理提供参考。方法提取全球疾病负担研究2019(GBD 2019)的数据,使用死亡及伤残致病寿命年(DALYs)的总数及年龄标准化率(ASR)来评估疾病负担情况,并进一步分析其在不同时间、性别、年龄的差异以及危险因素的变化。结果1990—2019年中国心房颤动/心房扑动导致的死亡数增加了3.55倍,DALYs数增加了3.12倍。死亡的ASR从1.49每10万人增加到1.66每10万人,DALYs的ASR则从43.34每10万人年增加到50.59每10万人年。归因于代谢性危险因素(收缩压和体重指数升高)的死亡数从0.55万人增加到2.02万人,DALYs数从23.55万人年增加到了79.49万人年。结论1990—2019年中国心房颤动/心房扑动疾病负担不断加重,代谢性危险因素是其最主要的危险因素。

Objective To systematically analyze the changes in the disease burden and risk factors of atrial fibrillation and atrial flutter(AF/AFL)in China from 1990 to 2019,and to provide reference for the treatment and management of the diseases.Methods Data from the Global Burden of Disease Study 2019(GBD 2019)were extracted to assess the burden of disease using the total numbers and age-standardized rates(ASR)of death and disability-adjusted life years(DALYs),and further analyzed differences in time,sex and age,as well as changes in risk factors.Results The number of deaths due to AF/AFL increased 3.55-fold,and the number of DALYs increased 3.12-fold in China from 1990 to 2019.The ASR of deaths increased from 1.49 per 100000 to 1.66 per 100000,and the ASR of DALYs increased from 43.34 to 50.59 per 100000 person-years.The number of deaths attributable to metabolic risk factors(elevated systolic blood pressure and body mass index)increased from 5.5 k to 20.2 k,and DALYs increased from 235.5 k to 794.9 k person-years.Conclusion The disease burden of AF/AFL continued to increase in China from 1990 to 2019,and metabolic risk factors were the predominant risk factors.