淋巴瘤自体造血干细胞移植指导原则

Guiding principles for autologous hematopoietic stem cell transplantation for lymphoma

自体造血干细胞移植(auto-HSCT)是治疗淋巴瘤的重要手段之一,在国内临床实践中的应用也日趋广泛。目前我国淋巴瘤auto-HSCT在整体的规范性和专业性方面与欧美等发达国家和地区尚有一定的差距,因此如何规范、合理应用auto-HSCT仍是国内临床医生面临的问题。基于国内主要auto-HSCT中心的经验和国内外相关研究进展,由中国临床肿瘤学会(CSCO)自体造血干细胞移植工作组牵头制定了该指导原则,从auto-HSCT的适应证、干细胞的动员与采集、干细胞的冻存与复苏、预处理、移植相关并发症、移植期间的护理等方面进行了总结,旨在指导临床医生更好地应用auto-HSCT治疗淋巴瘤,为患者带来最大获益。

Autologous hematopoietic stem cell transplantation(auto-HSCT)is an important therapeutic option for the treatment of lymphoma,and its application in domestic clinical practice is becoming more and more widespread.At present,there is still a gap in the overall standardization and professionalism of auto-HSCT for lymphoma between China and developed countries and regions such as America and Europe,so how to apply auto-HSCT in a standardized and rational manner is still a problem faced by domestic clinicians.Based on the experience of major auto-HSCT centers in China and related research progress at home and abroad,the guiding principles are developed by the Autologous Hematopoietic Stem Cell Transplantation Working Group of Chinese Society of Clinical Oncology(CSCO),which summarize the indications for auto-HSCT,mobilization and collection of stem cells,freezing and resuscitation of stem cells,transplantation conditioning,transplantation-related complications,and nursing care during transplantation.It aims to guide clinicians to better apply auto-HSCT for the treatment of lymphoma and bring maximum benefit to patients.