HOXB7和VEGF对肝细胞癌病人预后影响的研究

Effect of HOXB7 and VEGF on the prognosis of patients with HCC

目的:通过研究肝细胞癌病人同源盒基因B7(HOXB7)和血管内皮生长因子(VEGF)的表达,探讨其对肝细胞癌病人术后预后的影响。方法:收集74例肝细胞癌病人临床病理和生存数据,应用免疫组织化学对术后病理标本进行HOXB7和VEGF染色。分析影响病人预后的因素。结果:74例病人术后3年和5年总生存率分别为67.6%和48.6%。多因素分析显示,HOXB7(P<0.01,HR=1.139),VEGF(P<0.01,HR=1.192)、Child-Pugh分级(P<0.01,HR=4.100)、T分期(P<0.01,HR=4.317)、肿瘤数量(P<0.01,HR=2.639)是影响病人生存的独立危险因素。免疫组织化学染色显示,HOXB7和VEGF表达影响病人5年生存率。结论:HOXB7和VEGF过表达影响肝细胞癌病人生存率和预后,是预后不良的因素。

Objective:To investigate the effect of homeobox B7(HOXB7)and vascular endothelial growth factor(VEGF)expressions on the prognosis of patients with hepatocellular carcinoma(HCC)after operation.Methods:Seventy-four patients with HCC following surgical resection were enrolled.Clinicopathological and survival data were analyzed,and immunohistochemical staining method for HOXB7 and VEGF expressions measurement was performed on tissue microarray sections.Results:The 3-and 5-year overall survival rates in the 74 patients were 67.6%and 48.6%,respectively.Multivariate analysis revealed that HOXB7(P<0.01,HR=1.139)and VEGF(P<0.01,HR=1.192)expressions,Child-Pugh class(P<0.01,HR=4.100),T stage(P<0.01,HR=4.317),Tumor number(P<0.01,HR=2.639)were the independent prognostic factors for overall survival rate.Immunohistochemical staining results showed that the expressions of HOXB7 and VEGF influenced the 5-year survival rate.Conclusions:HOXB7 and VEGF overexpression affect the survival and prognosis of HCC patients,which suggesting a poor overall survival rate.