Correlation analysis of anxiety with psoriasis severity, oxidative stress and inflammatory factors in patients with psoriasis vulgaris

Objective:To investigate the anxiety status of patients with psoriasis vulgaris,and analyze the correlation between anxiety and severity of the disease,oxidative stress factors and inflammatory factors.Methods:From August 2021 to February 2022,84 patients with psoriasis in the Dermatology Department of Dongzhimen Hospital of Traditional Chinese Medicine were recruited.Hamilton anxiety scale(HAMA),psoriasis lesion area and severity index(PASI),VAS pruritus scale(VAS)were collected to detect serum malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH px),interleukin-6(IL-6),interleukin-17A(IL-17A),and tumor necrosis factor-α(TNF-α).Based on the HAMA score,a group controlled study and correlation analysis were conducted.In addition,the HAMA scores of 84 healthy people were collected for a controlled study.Results:HAMA score of patients with psoriasis vulgaris was higher than that of healthy people(Z=-7.730,P<0.05).There were differences in PASI,VAS scores,MDA,SOD,GSH px,IL-6,IL-17A secretion levels between psoriasis vulgaris patients with anxiety and psoriasis vulgaris patients without anxiety.HAMA score was positively correlated with PASI and VAS scores in patients with psoriasis vulgaris(r=0.564,0.513,P<0.05).It was positively correlated with MDA,IL-6,IL-17A in serum(r=0.390,0.355,0.248,P<0.05).It was negatively correlated with SOD and GSH px(r=-0.313,-0.502,P<0.05);and TNF-αnot relevant.Conclusion:The anxiety risk of psoriasis patients was higher than that of healthy people;anxiety is closely related to psoriasis,and is reflected in the skin lesions,itching,oxidative stress and inflammatory factor levels of psoriasis patients.The comorbidity mechanism of anxiety and psoriasis may be related to oxidative stress and up regulation of inflammatory factors.