硫酸镁注射液联合达肝素钠应用于重度子痫前期的临床观察

Clinical observation of magnesium sulfate injection combined with Dapheparin sodium in severe preeclampsia

目的探讨硫酸镁注射液联合达肝素钠应用于重度子痫前期的临床效果。方法选取62例重度子痫前期患者,按照随机数字表法将其分为对照组与研究组,每组31例。对照组给予硫酸镁治疗,研究组加用达肝素钠治疗。比较两组患者治疗前后的血压、24h尿蛋白量(24hUP)、治疗期不良反应发生情况及随访期间的妊娠结局。结果治疗前,两组收缩压(SBP)、舒张压(SDP)及24hUP水平比较,差异无统计学意义(P>0.05);治疗后,两组SBP、SDP及24h UP水平均低于治疗前,且研究组明显低于对照组,差异具有统计学意义(P<0.05)。研究组治疗期不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。研究组不良妊娠结局发生率6.45%低于对照组的25.81%,差异有统计学意义(P<0.05)。结论硫酸镁注射液联合达肝素钠治疗重度子痫前期可有效控制产妇血压水平,值得临床推广与应用。

Objective To investigate the clinical eflFect of magnesium sulfate injection combined with dapheparin sodium in severe preeclampsia.Methods 62 patients with severe preeclampsia were selected and divided into control group and study group according to random number table method,with 31 cases in each group.The control group was treated with magnesium sulfate and the study group was treated with dapheparin sodium.Blood pressure before and after treatment,24h urinary protein volume(24h UP),occurrence of adverse reactions during treatment and pregnancy outcome during follow-up were compared between the two groups.Results Before treatment,there were no significant differences in systolic blood pressure(SBP),diastolic blood pressure(SDP)and 24h UP between the two groups(P>0.05).After treatment,SBP,SDP and 24h UP levels in 2 groups were lower than before treatment,and the study group was significantly lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the study group was 6.45% lower than that in the control group(25.81%),and the difference was statistically significant(P<0.05).Conclusion Magnesium sulfate injection combined with dapheparin sodium in the treatment of severe preeclampsia can effectively control the level of maternal blood pressure,worthy of clinical promotion and application.