白细胞介素-1β与妊娠及其相关疾病的关系

The Relationship between Interleukin-1βand Pregnancy and Related Diseases

白细胞介素-1β(interleukin-1β,IL-1β)在多种组织和细胞中均可表达,具有生物活性的IL-1β通过与IL-1Ⅰ型受体结合进行信号传导,在炎症和免疫反应的启动和调节中起重要作用,参与维持整个妊娠期的母胎界面稳态。在一些病理妊娠中,IL-1β表达水平发生了改变。近年研究表明,IL-1β在蜕膜化、胚胎植入、滋养细胞侵袭以及胎盘形成等生理妊娠过程中起着重要的调控作用,而IL-1β异常表达可能通过破坏T细胞介导的免疫平衡、诱导滋养层功能障碍、促进羊膜中胶原蛋白的降解以及诱导内质网应激相关细胞凋亡等机制,参与复发性流产、子痫前期和早产等妊娠相关疾病的发生发展过程。综述IL-1β在生理妊娠过程中和各种妊娠相关疾病中的作用及其所涉及的分子机制,以期为进一步研究妊娠相关疾病的病理机制、预测及临床治疗提供参考。

Interleukin-1β(IL-1β)is expressable in a variety of tissues and cells.Bioactive signal of IL-1βis conducted by combining with IL-1RⅠ.It plays an important role in the initiation and regulation of inflammation and immune responses.IL-1βparticipates in maintaining maternal-fetal interface homeostasis throughout pregnancy.The expression level of IL-1βwas changed in some pathological pregnancy.Recent studies have shown that IL-1βplays an important role in the regulation of physiological pregnancy processes such as degeneration,embryo implantation,trophoblastic invasion and placental formation,and that the abnormal expression of IL-1βis related to the occurrence and development of pregnancy-related diseases such as recurrent abortion,pre-eclampsia and preterm birth.What′s more,the abnormal expression of IL-1βis also involved in the mechanisms of destroying T cell mediated immune balance,inducing trophoblast dysfunction,promoting the degradation of collagen in amniotic membrane,and inducing apoptosis of endoplasmic reticulum stress related cells.In this paper,the role of IL-1βin maintaining physiological pregnancy and its relationship with pregnancy-related diseases are reviewed in order to provide a reference for further research on the pathological mechanism,prediction and clinical treatment of pregnancy related diseases.