奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的效果

Effect of omeprazole combined with amoxicillin in the treatment of chronic superficial gastritis

目的 观察奥美拉唑联合阿莫西林对慢性浅表性胃炎的效果,为临床工作提供参考借鉴。方法 纳入山东省高唐县人民医院2020年1月—2021年1月收治的86例慢性浅表性胃炎患者进行本次临床研究,以抽签法分成观察组和对照组,每组各43例。对照组患者给予奥美拉唑治疗,观察组患者给予奥美拉唑联合阿莫西林治疗。统计分析两组的治疗效果、不良反应发生率(皮疹、腹泻、嗜睡)以及复发率。结果 观察组治疗总有效率为93.02%,高于对照组的65.12%,差异有统计学意义(χ^(2)=10.117 6,P<0.05)。观察组患者不良反应发生率为9.30%,低于对照组的25.58%,差异有统计学意义(χ^(2)=3.956 8,P<0.05)。观察组患者复发率为11.63%,低于对照组的39.53%,差异有统计学意义(χ^(2)=8.795 5,P<0.05)。结论 在慢性浅表性胃炎治疗上采用奥美拉唑联合阿莫西林效果更为明显,与单一用药治疗相比,其效果更好且不良反应与复发率更低,建议推广应用。

Objective To observe the effect of omeprazole combined with amoxicillin on chronic superficial gastritis and provide reference for clinical work. Methods A total of 86 patients with chronic superficial gastritis treated in Gaotang County People’s Hospital from January 2020 to January 2021 were included in this clinical study. They were divided into observation group and control group by drawing lots,with 43cases in each group. The patients in the control group were treated with omeprazole,and the patients in the observation group were treated with omeprazole combined with amoxicillin. The treatment effect,the incidence of adverse reactions(nausea and vomiting,abdominal distension,anorexia)and the recurrence rate of the two groups were statistically analyzed. Results The total effective rate in the observation group was 93.02%,which was higher than 65.12% in the control group,and the difference was statistically significant(χ^(2)=10.117 6,P<0.05). The incidence of adverse reactions in the observation group was 9.30%,which was lower than 25.58% in the control group,and the difference was statistically significant(χ^(2)=3.956 8,P<0.05). The recurrence rate in the observation group was 11.63%,which was lower than39.53% in the control group,and the difference was statistically significant (χ^(2)=8.795 5,P <0.05).Conclusion Omeprazole combined with amoxicillin was more effective in the treatment of chronic superficial gastritis. Compared with single drug treatment,it had better effect,less side effects and lower recurrence rate. It was recommended to be popularized.