微波联合七叶皂苷钠治疗中老年带状疱疹的临床疗效观察

Observation on the clinical effect of microwave combined with sodium aescinate on treatment of herpes zoster in middle and elderly patients

目的观察微波联合七叶皂苷钠对中老年带状疱疹的治疗效果。方法选择2018年9月至2022年3月中国人民解放军63750部队医院收治的带状疱疹患者120例,采用随机数字表法将其分为观察组和对照组,每组60例。对照组接受抗病毒、营养神经治疗。观察组在对照组治疗方案基础上给予微波联合七叶皂苷钠治疗。于治疗前和治疗后第1、2周对两组进行皮肤病生活质量指数(DLQI)、数字评定量表(NRS)和语言描述分级量表(VRS)评分,比较两组疼痛缓解时间、结痂时间、皮损消退时间以及后遗神经痛(PHN)发生率。结果经治疗后,两组DLQI、NRS、VRS评分均较治疗前下降,且观察组评分下降幅度更大(P<0.05)。在治疗后第1、2周,观察组DLQI、NRS、VRS评分均低于对照组,差异有统计学意义(P<0.05)。观察组疼痛缓解时间、疱疹结痂时间、皮损消退时间均短于对照组,差异有统计学意义(P<0.05)。在皮损消退后4周,对照组有6例(10.00%)发生PHN,观察组有2例(3.33%)发生PHN,两组PHN发生率比较差异无统计学意义(χ^(2)=1.205,P=0.272)。两组不良反应发生率比较差异无统计学意义(5.00%vs 3.33%;χ^(2)=0.000,P=1.000)。结论微波联合七叶皂苷钠治疗可有效减轻带状疱疼痛症状,促进疱疹结痂及皮损愈合,提高患者的生活质量。

Objective To observe the therapeutic effect of microwave combined with sodium aescinate on herpes zoster in middle and elderly patients.Methods One hundred and twenty patients with herpes zoster admitted to the 63750th Military Hospital of the People′s Liberation Army of China from September 2018 to March 2022 were selected and divided into observation group and control group by random number table method,with 60 cases in each group.The control group received antiviral and nutritional neurotherapy,and the observation group received microwave treatment combined with sodium aescinate on the basis of the treatment plan of the control group.Dermatology Life Quality Index(DLQI)score,Numerical Rating Scale(NRS)score and Verbal Rating Scale(VRS)score were performed on both groups before treatment,and 1 week and 2 weeks after treatment.The pain relief time,herpes scab time,skin fading time and the incidence of post-herpetic neuralgia(PHN)were compared between the two groups.Results After treatment,the scores of DLQI,NRS and VRS in both groups decreased compared with those before treatment,and the scores of the observation group decreased more significantly(P<0.05).The DLQI,NRS and VRS scores of the observation group were lower than those of the control group 1 week and 2 weeks after treatment,and the differences were statistically significant(P<0.05).The pain relief time,herpes scab time and skin fading time in the observation group were shorter than those in the control group,and the differences were statistically[JP4]significant(P<0.05).Six cases(10.00%)in the control group developed PHN,and 2 cases(3.33%)in the observation group developed PHN 4 weeks after the skin lesions subsided,and there was no significant difference in the incidence of PHN between the two groups(χ^(2)=1.205,P=0.272).There was no significant difference in the incidence of adverse reactions between the two groups(5.00%vs 3.33%;χ^(2)=0.000,P=1.000).Conclusion Microwave combined with sodium aescinate treatment can effectively relieve the pain symptoms of herpes zoster,promote the healing of herpes scab and skin lesions,and improve the quality of life of the patients.