足细胞内陷性肾小球病1例

A case of podocyte infolding glomerulopathy

足细胞内陷性肾小球病(podocyte infolding glomerulopathy,PIG)是近年提出的一种足细胞独立病理类型的肾小球病,特征是电镜下观察到足细胞相关的超微结构如微球、微管折叠进入肾小球基底膜(glomerular basement membrane,GBM)。目前国内外关于此病的报道尚不多见,且多集中在日本。PIG的临床特点、发病机制尚不明确。本文报道了1例临床表现为肾病综合征患者,肾活检提示为PIG,经糖皮质激素、羟氯喹联合他克莫司治疗后患者临床症状缓解,尿蛋白减少。

Podocyte infolding glomerulopathy(PIG)is a pathologic type of podocyte glomerulopathy reported recently.The characteristic is that the ultrastructure related to podocytes,such as microspheres and microtubules,are folded into the glomerular basement membrane(GBM)under electron microscope.At present,there are few reports about this disease at home and abroad,and most of them are concentrated in Japan.The clinical characteristics and pathogenesis of PIG are still unclear.In this paper,we report a case of clinical manifestations of nephrotic syndrome,renal biopsy indicated PIG,after the treatment of glucocorticoid,hydroxychloroquine and tacrolimus,the patient's clinical symptoms were relieved and urinary protein decreased.