从免疫性炎症疾病复发特征试论中医伏邪的生物学基础

Discussion on Biological Basis of Insidious Pathogen in Chinese Medicine from Recurrence Characteristics of Immune Infammatory Disease

伏邪在中医学理论中释义为藏伏于体内而不立即发病的病邪,是中医致病的病因之一。伏邪所致疾病具有隐伏潜伏、病程缠绵、暗耗、杂合等特点,但关于伏邪具体的生物学基础研究较少。近年来研究发现适应性免疫系统中组织定居记忆T细胞(TRM细胞)在内伤杂病,尤其是免疫性炎症疾病复发中起到了关键性作用,颇具伏邪之特点,两者在导致疾病复发的特征上也有相似性。TRM细胞是否为伏邪的生物学基础呢?对此笔者将二者放在一起对比与分析,并结合免疫性疾病复发模型-方药的实验研究,探讨伏邪与TRM细胞的关联性。

Insidious pathogen is interpreted in the theory of Chinese medicine(CM) as a pathogen that is exposed to pathogens but does not occur instantaneously,instead is hidden in the body. The terminology is one of the causes of disease in CM. The diseases caused by insidious pathogen have the characteristics of invisibility,lingering course,internal friction,heterozygous,etc. However,there are few specific biological basic researches on insidious pathogen. In recent years,studies have found that the tissue resident memory T cells(TRMcells)in the adaptive immune system play a key role in internal injuries and miscellaneous diseases,especially in the recurrence of immune diseases. They have the characteristics of insidious pathogen,and both of them lead to the recurrence of the disease. There is also a high degree of similarity in the characteristics. Are TRMcells the biological basis of insidious pathogen? In this regard,the authors compare and analyze these two concepts,and combine our experimental research on the previous disease model-prescription to explore the relationship between insidious pathogen and TRMcells.