摘要
慢性心力衰竭是各种心脏疾病进展到终末期的一系列临床综合征,其发病率和病死率逐年增加,严重威胁人类的生命健康。诱发慢性心力衰竭的基础疾病复杂多样,包括冠心病、高血压病、糖尿病、心肌病等,其发病机制不尽相同,根据不同病因建立与之相匹配的慢性心力衰竭动物模型,对探究慢性心力衰竭的病理生理机制以及中医药应用于防治慢性心力衰竭具有重要的指导意义。因此,该文以心力衰竭的病因为分类依据,总结了近十年来使用较多的慢性心力衰竭动物模型,以及这些动物模型在中医药研究中的应用,以期为研究慢性心力衰竭的发病机制和治疗手段提供思路。
Chronic heart failure(CHF) is a series of clinical syndromes in which various heart diseases progress to their end stage. Its morbidity and mortality are increasing year by year, which seriously threatens people′s life and health. The diseases causing CHF are complex and varied, such as coronary heart disease, hypertension, diabetes, cardiomyopathy and so on. It is of great significance to establish animal models of CHF according to different etiologies to explore the pathogenesis of CHF and develop drugs to prevent and treat CHF induced by different diseases. Therefore, based on the classification of the etiology of CHF, this paper summarizes the animal models of CHF widely used in recent 10 years, and the application of these animal models in traditional Chinese medicine(TCM) research, in order to provide ideas and strategies for studying the pathogenesis and treatment of CHF, and provide ideas for TCM modernization research.
作者
张倩
卫晓红
陈洁
吴雪芬
夏小凤
武玉卓
王玲燕
夏欢
夏桂阳
林生
商洪才
ZHANG Qian;WEI Xiao-hong;CHEN Jie;WU Xue-fen;XIA Xiao-feng;WU Yu-zhuo;WANG Ling-yan;XIA Huan;XIA Gui-yang;LIN Sheng;SHANG Hong-cai(Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第3期614-624,共11页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82073978,82104441)
国家重点研发计划“中医药现代化研究”重点专项(2017YFC1700400)
中国博士后科学基金项目(2020TQ0056,2021M700522)。
关键词
慢性心力衰竭
动物模型
病因
发病机制
心衰发展危险因素
中医药研究
chronic heart failure
animal models
etiology
pathogenesis
risk factors for CHF development
traditional Chinese medicine