慢性心力衰竭常用动物模型的研究进展及其在中医药研究中的应用

Advances in animal models of chronic heart failure and its applications in traditional Chinese medicine

慢性心力衰竭是各种心脏疾病进展到终末期的一系列临床综合征,其发病率和病死率逐年增加,严重威胁人类的生命健康。诱发慢性心力衰竭的基础疾病复杂多样,包括冠心病、高血压病、糖尿病、心肌病等,其发病机制不尽相同,根据不同病因建立与之相匹配的慢性心力衰竭动物模型,对探究慢性心力衰竭的病理生理机制以及中医药应用于防治慢性心力衰竭具有重要的指导意义。因此,该文以心力衰竭的病因为分类依据,总结了近十年来使用较多的慢性心力衰竭动物模型,以及这些动物模型在中医药研究中的应用,以期为研究慢性心力衰竭的发病机制和治疗手段提供思路。

Chronic heart failure(CHF) is a series of clinical syndromes in which various heart diseases progress to their end stage. Its morbidity and mortality are increasing year by year, which seriously threatens people′s life and health. The diseases causing CHF are complex and varied, such as coronary heart disease, hypertension, diabetes, cardiomyopathy and so on. It is of great significance to establish animal models of CHF according to different etiologies to explore the pathogenesis of CHF and develop drugs to prevent and treat CHF induced by different diseases. Therefore, based on the classification of the etiology of CHF, this paper summarizes the animal models of CHF widely used in recent 10 years, and the application of these animal models in traditional Chinese medicine(TCM) research, in order to provide ideas and strategies for studying the pathogenesis and treatment of CHF, and provide ideas for TCM modernization research.