平肝活血方治疗合并卵圆孔未闭-右向左分流-Ⅰ级偏头痛的临床观察

Clinical observation of Pinggan Huoxue Decoction in treatment of migraine combining PFO-RLS-Level I

目的:观察平肝活血方对合并卵圆孔未闭(PFO)-右向左分流(RLS)-Ⅰ级偏头痛患者的临床疗效。方法:采用回顾性病例系列研究方法,对190例合并PFO-RLS的偏头痛患者进行初步证候归纳,进而纳入61例肝风血瘀证且经平肝活血方干预的合并PFO-RLS-Ⅰ级偏头痛患者,对其临床信息进行分析,比较其干预前后14 d的头痛发作次数,以及入组后0、7、14、21 d各时点的头痛视觉模拟评分(VAS)。结果:肝风血瘀证是合并PFO-RLS偏头痛患者最常见的证型,占比为37.37%(71/190);与干预前比较,平肝活血方干预后患者头痛发作次数显著减少(P<0.01),干预后7、14、21 d VAS评分显著降低(P<0.01)。结论:平肝活血方可有效减轻合并PFO-RLS-Ⅰ级偏头痛患者的疼痛程度及发作次数。

Objective:Observing clinical effect of Pinggan Huoxue Decoction(PGHXD)in treatment of Migraine combining PFO-RLS-Level I.Methods:The retrospective case series study method was adopted,a total of 190 patients with migraine complicated with PFO-RLS were summarized,and totally 61 liver wind and blood stasis syndrome cases of Migraine combining PFO-RLS-Level I treated by PGHXD were included.Then compared the number of headache attacks 14 days before and after treatment administration.In addition,the VAS score of headache on day 0,day 7,day 14,day 21 after case included was also recorded.Results:Liver wind and blood stasis syndrome was the most common syndrome type in migraine patients with PFO-RLS,accounting for 37.37%(71/190).The number of headache attacks dropped significantly after intervention and was statistically significant between groups(P<0.01).The VAS scores at baseline and 7,14,and 21 days after intervention were statistically analyzed.PGHXD could effectively reduce the VAS score of headache.Conclusion:PGHXD can alleviate headache and decrease number of headache attack in patient with migraine combining PFO-RLS-Level I.