白细胞介素在椎间盘退变中的作用

Role of interleukin in intervertebral disc degeneration

椎间盘退变引起的下腰痛严重影响着老年患者的健康,同样也给社会和家庭带来巨大的负担。椎间盘退变从18岁开始,由于年龄、生物力学、生物化学、自身免疫炎症反应和遗传易感等因素的影响,加速椎间盘退变的过程。椎间盘退变是一个序贯、级联发生的病理过程,从椎间盘细胞微环境的改变开始,发展为椎间盘结构和功能的改变,其主要病理特征是炎症细胞因子,如白细胞介素(interleukins,ILs)的释放,促分解代谢酶的表达增加,细胞外基质降解,椎间盘细胞凋亡等。在椎间盘退变过程中白细胞介素起到了重要作用,本文将对白细胞介素在椎间盘退变中的作用进行综述。

Low back pain caused by intervertebral disc degeneration seriously affects the health of elderly patients,but also brings a huge burden to society and family.Intervertebral disc degeneration begins at age 18,and is accelerated by the age,with biomechanics,bio⁃chemistry,autoimmune inflammatory response and genetic predisposition factors.Intervertebral disc degeneration is a sequential,cascade pathological process that starts with changes in the microenvironment of intervertebral disc cells and progresses to changes in intervertebral disc structure and function.A major pathological feature is the release of inflammatory cytokines such as interleukin,which increased ex⁃pression of catabolic enzymes,degradation of extracellular matrix,and intervertebral disc cell apoptosis.As interleukins(ILs)plays an im⁃portant role in intervertebral disc degeneration,this article reviews the effect of interleukin on intervertebral disc degeneration.