间充质干细胞外泌体在肝癌中作用的研究进展

Research progress on the role of mesenchymal stem cell exosomes in liver cancer

肝细胞癌作为人类恶性肿瘤之一,具有侵袭性强、化疗敏感性差、复发率高、死亡率高等特点。因此,确定治疗肝癌的新靶点对于探索治疗新策略具有重要意义。外泌体是重要的物质运输载体,参与肝癌细胞增殖、分化、凋亡等过程,影响化疗药物敏感性,可能是治疗肝癌的理想途径。该文就间充质干细胞外泌体对肝癌的影响进行了综述。

As one of human malignant tumors,hepatocellular carcinoma has the characteristics of strong invasion,poor chemosensitivity,high recurrence rate and high mortality rate.Therefore,it is of great significance to determine new targets for the treatment of liver cancer for exploring new treatment strategies.Exosomes are important material transport carriers,participate in the proliferation,differentiation,apoptosis and other processes of liver cancer cells,affect the sensitivity of chemotherapy drugs,and may be an ideal way to treat liver cancer.The article reviews the effects of mesenchymal stem cell exosomes on liver cancer.