ICU心力衰竭患者抑郁症发病率及其影响因素分析

Analysis of Incidence of Depression and Its Influencing Factors in ICU Patients with Heart Failure

目的:探讨ICU心力衰竭患者抑郁症发病率及其影响因素。方法:选取Dryad数据库的心力衰竭患者1177例为观察对象,根据患者是否并发抑郁症分为抑郁症组(n=140)与非抑郁症组(n=1037)。收集两组临床资料,进行单因素分析、多因素logistic回归分析。结果:抑郁症组年龄、平均血红蛋白浓度、血肌酐、尿素氮、血镁水平低于非抑郁症组,女性患者占比、贫血患者占比、舒张压、血小板计数、pH值高于非抑郁症组,凝血酶原时间短于非抑郁症组,差异有统计学意义(P<0.05)。多因素logistic回归结果显示,患者较高的年龄,较高的平均血红蛋白浓度,凝血酶原时间延长,可能为发生抑郁的保护因素。女性,较低的血镁浓度,较高的pH值可能为发生抑郁的危险因素(P<0.05)。结论:患者较高的年龄,较高的平均血红蛋白浓度,凝血酶原时间延长,可能为发生抑郁的保护因素。女性,较低的血镁浓度,较高的pH值,可能为发生抑郁的危险因素。

Objective:To investigate the incidence of depression and its influencing factors in ICU patients with heart failure.Methods:One thousand one hundred and seventy-seven heart failure patients from Dryad database were selected as observation subjects and divided into depression group(n=140)and non-depression group(n=1037)according to whether the patients had concomitant depression or not.Clinical data of both groups were collected for univariate analysis and multivariate logistic regression analysis.Results:Age,mean hemoglobin concentration,blood creatinine,urea nitrogen,and blood magnesium levels in the depression group were lower than those in the non-depression group,and the percentage of female patients,the percentage of anemic patients,diastolic blood pressure,platelet count,and pH value in the depression group were higher than those in the nondepression group,and prothrombin time in the depression group was shorter than that in the non-depression group,with statistically significant differences(P<0.05).Multivariate logistic regression results showed that higher age,higher mean hemoglobin concentration,and prolonged prothrombin time may be protective factors for the development of depression.Female,lower blood magnesium concentration,and higher pH value may be risk factors for the development of depression(P<0.05).Conclusion:Higher age,higher mean hemoglobin concentration,and prolonged prothrombin time may be protective factors for the development of depression in patients.Female,lower blood magnesium concentration,and higher pH value may be risk factors for the development of depression.