右美托咪定对谵妄患者血流动力学的影响

Effects of Dexmedetomidine on Hemodynamics in Patients with Delirium

目的:分析右美托咪定对谵妄患者的血流动力学的影响。方法:选取2020年1月-2021年2月宿迁医院门诊收治的谵妄患者120例作为研究对象,按照随机数字表法分为对照组和观察组,各60例。观察组给予右美托咪定治疗,对照组给予等剂量生理盐水。比较两组患者总住院时间、Richmond躁动-镇静评分(RASS)、不良反应发生率及血流动力学指标[平均动脉压(MAP)、心率(HR)、收缩压(SBP)和舒张压(DBP)]。结果:观察组患者总住院时间短于对照组,RASS评分、不良反应发生率低于对照组,差异有统计学意义(P<0.05);给药后10 min、20 min,观察组MAP高于对照组,差异有统计学意义(P=0.000);给药后10 min、20 min、30 min、45 min,观察组HR高于对照组,差异有统计学意义(P<0.05);给药后10 min、20 min、30 min,观察组SBP低于对照组,差异有统计学意义(P=0.000);给药后20 min、30 min,观察组DBP低于对照组,差异有统计学意义(P=0.000)。结论:右美托咪定治疗谵妄患者能明显缩短总住院时间,降低不良反应发生率,且患者血流动力学稳定。

Objective:To analyze the effect of dexmedetomidine on the hemodynamics in patients with delirium.Methods:One hundred and twenty patients with delirium admitted to the outpatient clinic of Suqian Hospital from January 2020 to February 2021 were selected as study subjects and divided into control group and observation group according to the random number table method,with sixty cases in each group.The observation group was given dexmedetomidine treatment and the control group was given equal doses of physiological saline.The total length of hospital stay,Richmond agitation-sedation score(RASS),incidence of adverse reactions and hemodynamic indexes[mean arterial pressure(MAP),heart rate(HR),systolic blood pressure(SBP)and diastolic blood pressure(DBP)]were compared between the two groups.Results:The total length of hospital stay of patients in the observation group was shorter than that in the control group,and the RASS score and incidence of adverse reactions in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).At 10 min and 20 min after administration,MAP in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.000).From 10 min,20 min,30 min and 45 min after administration,HR in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).From 10 min,20 min and 30 min after administration,SBP in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.000).At 20 min and 30 min after administration,DBP in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.000).Conclusion:Dexmedetomidine in the treatment of delirium patients can significantly shorten the total length of hospital stay,reduce the incidence of adverse reactions,and stabilize hemodynamics.