摘要
动脉粥样硬化(As)是一种与炎症、氧化应激和血流剪切力等多种损伤因素密切相关的血管局灶性病变。越来越多的研究显示,多种心血管系统之外其他器官的疾病具有较高并发As的风险。本综述从内皮炎症和氧化应激的角度对呼吸系统疾病、消化系统疾病、泌尿和生殖系统疾病、自身免疫性疾病和代谢性疾病等并发As的机制进行了总结。
Atherosclerosis(As)is a focal vascular disease that closely related to many injury factors such as endothelial inflammation,oxidative stress,and shear stress.More and more studies have shown that the risk of As is higher in a variety of non-cardiovascular diseases.This review summarizes the mechanism of As in respiratory system diseases,digestive system diseases,urinary and reproductive system diseases,autoimmune diseases and metabolic diseases from the perspective of endothelial inflammation and oxidative stress.
作者
王梦艳
刘杰
黄聿
张城林
WANG Mengyan;LIU Jie;HUANG Yu;ZHANG Chenglin(Department of Pathophysiology,Shenzhen University Health Science Center,Shenzhen,Guangdong 518060,China;Department of Biomedical Sciences,City University of Hong Kong,Hong Kong 999077,China;Shenzhen Research Institute,The Chinese University of Hong Kong,Shenzhen,Guangdong 518057,China)
出处
《中国动脉硬化杂志》
CAS
2023年第4期287-296,共10页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82000056和81970250)
中国香港研究资助局面上项目(14109720和14100121)
深圳大学青年教师科研启动基金项目(000002111702和0000002100178)。
关键词
血管内皮
炎症
氧化应激
动脉粥样硬化
非血管性疾病
vascular endothelium
inflammation
oxidative stress
atherosclerosis
non-vascular diseases
