气体信号分子与动脉粥样硬化

Gasotransmitters and atherosclerosis

气体信号分子是一类相对分子质量小、可自由穿过生物膜、跨细胞或细胞器运输不完全依赖膜受体或转运体的内源性信号转导物质。气体信号分子发挥效应多样、作用机制复杂,针对其研究一直是领域热点。文章将重点论述一氧化氮、一氧化碳和硫化氢三种气体信号分子在动脉粥样硬化中的作用及分子机制。

Gasotransmitters are a class of endogenous signal transduction molecules with low-molecular weight,which can freely permeable to biological membranes of cells.As such,their intercellular and intracellular movements do not exclusively rely on membrane receptors or other transporters.Gasotransmitters have multiple molecular effects with a diversity of mechanisms,and researches of them have always been hotspots in the cardiovascular field.This review will introduce the research progressions of gasotransmitters in atherosclerosis,with emphasis on nitric oxide,carbon monoxide and hydrogen sulfide.