IGF-Ⅰ、Anti-HBs及IL-4对乙型肝炎的诊断价值

Diagnostic value of IGF-Ⅰ,Anti-HBs and interleukin-4 in hepatitis B

目的探讨胰岛素样生长因子Ⅰ(IGF-Ⅰ)、乙型肝炎病毒表面抗原抗体(Anti-HBs)以及微环境因子白细胞介素-4(IL-4)对乙型肝炎的诊断价值,以期为临床治疗提供参考。方法本研究选择大连市第五人民医院2019年2月—2022年2月收治的71例乙型肝炎患者作为研究组研究对象,另选同期于该院进行体检的50例健康个体为对照组研究对象。比较2组研究对象IGF-Ⅰ、Anti-HBs及IL-4水平;采用绘制ROC曲线的方式分别计算IGF-Ⅰ、Anti-HBs及IL-4水平对乙型肝炎的诊断效能;通过Pearson相关分析探究乙型肝炎患者IGF-Ⅰ、Anti-HBs及IL-4水平的相关性。结果研究组患者IGF-Ⅰ及IL-4水平均高于对照组,而Anti-HBs水平低于对照组,差异有统计学意义(P<0.05)。分别绘制IGF-Ⅰ、AntiHBs及IL-4水平诊断乙型肝炎的ROC曲线,结果显示IGF-Ⅰ、Anti-HBs及IL-4水平诊断乙型肝炎的AUC分别为0.9133(P<0.001)、0.9500(P<0.001)、0.7067(P=0.006)。Pearson相关分析结果显示,乙型肝炎患者IGF-Ⅰ、AntiHBs及IL-4呈明显相关性,其中IGF-Ⅰ与Anti-HBs呈负相关关系(r=-0.5363,P<0.001),与IL-4呈正相关关系(r=0.2826,P<0.001),Anti-HBs与IL-4呈负相关关系(r=-0.2408,P<0.001)。结论IGF-Ⅰ、Anti-HBs以及IL-4水平在乙型肝炎患者中呈现异常表达状态,且相互之间存在明显的相关性,可以考虑将它们应用于乙型肝炎的鉴别诊断中。

Objective To investigate the diagnostic value of insulin-like growth factor I(IGF-Ⅰ),antibody to hepatitis B surface antigen(Anti-HBs),and interleukin-4(IL-4)in hepatitis B to provide guidance for clinical treatment.Methods Seventy-one patients with hepatitis B admitted to the Fifth People's Hospital of Dalian from February 2019 to February 2022 were selected as the study group,and another 50 healthy individuals who underwent physical examination in our hospital during the same period were selected as controls.The levels of IGF-Ⅰ,Anti-HBs and IL-4 in the two groups were compared;the levels of IGF-Ⅰ,Anti-HBs and IL-4 in the diagnosis of hepatitis B were calculated by plotting the ROC curve,respectively.The correlation of IGF-Ⅰ,Anti-HBs and IL-4 levels in patients with hepatitis B was explored by Pearson correlation analysis.Results The levels of IGF-Ⅰand IL-4 in the study group were higher than those in the control group,while the level of Anti-HBs was lower than that in the control group,with statistical significance(P<0.05).ROC curves were plotted for IGF-Ⅰ,Anti-HBs and IL-4 levels in the diagnosis of hepatitis B.The results showed that the AUCs of IGF-Ⅰ,Anti-HBs and IL-4 levels in the diagnosis of hepatitis B were 0.9133(P<0.001),0.9500(P<0.001)and 0.7067(P=0.006),respectively.The results of Pearson correlation analysis indicated that IGF-Ⅰ,Anti-HBs and IL-4 were significantly correlated in patients with hepatitis B,in which IGF-Ⅰwas negatively correlated with Anti-HBs(r=-0.5363,P<0.001),positively correlated with IL-4(r=0.2826,P<0.001),and anti-HBs was negatively correlated with IL-4(r=-0.2408,P<0.001).Conclusion The levels of IGF-Ⅰ,Anti-HBs,and IL-4 are abnormally expressed in patients with hepatitis B,and a significant correlation was observed between them,which can be considered to be applied in the differential diagnosis of hepatitis B.