槲皮素基于内质网应激信号通路调节动物机体健康和疾病的研究进展

Research Progress of Quercetin in Regulating Animal Health and Diseases Based on Endoplasmic Reticulum Stress Signaling Pathway

内质网是蛋白质和脂质生物合成以及跨膜蛋白折叠的场所。生理和病理情况都可影响内质网的功能,导致内质网应激。长期和严重内质网应激可导致细胞的自噬和/或诱导细胞凋亡。多项研究表明,内质网应激是导致许多疾病的主要因素。因此,对内质网应激通路的调节已成为一个潜在的治疗靶点。槲皮素是属于黄酮类植物衍生的次生代谢物,具有一系列有益作用。近年来的研究发现,槲皮素可通过调控内质网应激信号,降低机体发生癌症、肝脏和胰腺疾病、心血管疾病、肠道疾病的风险,减少器官/组织损伤,进而维持动物机体健康。本文主要综述槲皮素调节动物内质网应激中的作用机制及研究进展,旨在为槲皮素的进一步开发利用和治疗动物内质网应激相关疾病方面提供参考。

The endoplasmic reticulum(ER)was the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded.Both pathological and physiological situations may disturb the function of the ER,resulting in endoplasmic reticulum stress(ERS).However,prolonged and severe ERS can lead to autophagy and/or the induction of cell apoptosis.Several studies implicated ERS as a major factor contributing to many diseases.Therefore,the modulation of ERS pathways has become a potential therapeutic target.Quercetin is a plant-derived secondary metabolite,which belongs to the flavonoids class which presents a range of beneficial effects.The finding of research in recent years,quercetin can decrease the body risk of cancer,liver and pancreas disease,cardiovascular disease,intestinal disease,and reduce organ/tissue damage by regulating ERS signaling,and maintain animal health.The present study mainly reviewed the action mechanism and research progress of quercetin regulating the ERS in animals.The review is aimed to provide a reference for the further development and utilization of quercetin,and also provide a new perspective for animals in treatment of ERS related diseases.[Chinese Journal of Animal Nutrition,2023,35(3):1413-1425]