肿瘤坏死因子-α在恶性肿瘤中的作用及意义

The role and significance of tumor necrosis factor⁃αin malignant tumor

肿瘤坏死因子-α(TNF-α)是一种主要由体内单核巨噬细胞产生的炎症因子,可以直接杀伤肿瘤细胞,在生理剂量下对正常细胞几乎没有毒性作用。TNF-α通过多种机制在肿瘤细胞的增殖、侵袭、转移及凋亡等过程中发挥重要作用,其既可以诱导肿瘤细胞凋亡,又可以促进肿瘤细胞的生长和侵袭。本文阐述TNF-α与恶性肿瘤相关的信号途径和TNF-α在恶性肿瘤中的双重作用及其在肿瘤治疗方面的应用现状,旨在为临床开发TNF-α相关抗癌药物提供新思路。

Tumor necrosis factor⁃α(TNF⁃α)is an inflammatory factor mainly produced by mono⁃nuclear macrophages in the body,which can directly kill tumor cells and has almost no toxic effect on normal cells at physiological doses.TNF⁃αplays an important role in various stages of tumor development,such as tumor cell proliferation,invasion,metastasis and apoptosis,through a variety of mechanisms.The factor not only promotes the apoptosis of tumor cell,but also promotes the growth and in⁃vasion of tumor cells.In this paper,the signaling pathways related to TNF⁃αin malignant tumors and its dual roles in malignant tumors and application in tumor treatment were elaborated.These findings may provide new ideas for the clinical development of anti⁃cancer drugs related to TNF⁃α.