桂枝茯苓胶囊加黄连素临床治疗多囊卵巢综合征的疗效观察

Clinical observation of the effect of Guizhi Poria Capsule plus berberine on polycystic ovary syndrome

目的探讨罹患多囊卵巢综合征的患者采用桂枝茯苓胶囊加黄连素治疗的效果。方法选取100例罹患多囊卵巢综合征患者,根据随机数字表法分为对照组与观察组,每组50例。对照组采用二甲双胍和克罗米芬进行治疗,观察组采用桂枝茯苓胶囊加黄连素、克罗米芬进行治疗。比较两组治疗效果、治疗后优势卵泡直径及子宫内膜厚度、空腹血糖水平、空腹血胰岛素水平、胰岛素抵抗指数、胰岛素敏感指数情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组优势卵泡直径和子宫内膜厚度均优于对照组,差异有统计学意义(P<0.05)。观察组空腹血糖、血胰岛素、胰岛素抵抗指数均低于对照组,胰岛素敏感指数高于对照组,差异有统计学意义(P<0.05)。结论多囊卵巢综合征患者采用桂枝茯苓胶囊加黄连素治疗效果较好,可改善患者优势卵泡直径和子宫内膜厚度,并可改善患者的空腹血糖、空腹血胰岛素水平及胰岛素抵抗指数、胰岛素敏感指数,值得临床推广与使用。

Objective To investigate the efiect of cassia poria capsule plus berberine in the treatment of patients with polycystic ovary syndrome.Methods A total of 100 patients with polycystic ovary syndrome were selected and divided into control group and observation group with 50 cases in each group according to random number table method.The control group was treated with metformin and clomiphene,and the observation group was treated with cassia branch poria capsule plus berberine and clomiphene.Treatment effect,dominant follicle diameter and endometrial thickness,fasting blood glucose level,fasting blood insulin level,insulin resistance index and insulin sensitivity index were compared between the two groups after treatment.Results The total efiective rate of observation group was higher than control group,the difference was statistically significant(P<0.05).After treatment,the dominant follicle diameter and endometrial thickness in the observation group were better than those in the control group,with statistical significance(P<0.05).Fasting blood glucose,blood insulin and insulin resistance index in the observation group were lower than those in the control group,while insulin sensitivity index was higher than that in the control group,with statistical significance(P<0.05).Conclusion The treatment effect of cassia Tuckaia capsule plus berberine is better in the patients with polycystic ovary syndrome,which can improve the dominant follicle diameter and endometrial thickness,and improve the fasting blood glucose,fasting blood insulin,insulin resistance index and insulin sensitivity index of the patients.It is worthy of clinical promotion and use.