妊娠期甲减孕妇血清铁蛋白水平与甲状腺功能指标的相关性分析

Correlation analysis of serum ferritin level and thyroid function index in women with hypothyroidism during pregnancy

目的探讨妊娠期甲状腺功能减退(甲减)孕妇血清铁蛋白水平与甲状腺功能指标的相关性。方法选取定期产检的280例妊娠期甲状腺功能减退孕妇作为观察组,其中妊娠早期98例、妊娠中期96例、妊娠晚期86例。另选取同期280例健康体检孕妇作为对照组,其中妊娠早期98例、妊娠中期96例、妊娠晚期86例。所有孕妇均进行血清铁蛋白以及甲状腺激素[游离甲状腺素(FT4)、促甲状腺激素(TSH)]检测。比较两组妊娠早期、中期、晚期孕妇的血清铁蛋白水平,并分析观察组孕妇血清铁蛋白水平与甲状腺功能指标的相关性。结果两组妊娠早期、中期、晚期孕妇的血清铁蛋白水平均呈下降趋势,且观察组妊娠早期、中期、晚期孕妇血清铁蛋白水平分别为(14.02±6.40)、(11.89±3.23)、(8.77±1.90)μg/L,均低于对照组的(54.55±6.97)、(17.26±2.78)、(11.07±1.56)μg/L,差异均具有统计学意义(P<0.05)。Pearson分析显示,观察组妊娠早期、中期孕妇的血清铁蛋白水平与FT4水平呈正相关(r=0.304、0.391,P=0.038、0.047<0.05),妊娠中期孕妇血清铁蛋白水平与TSH水平呈负相关(r=-0.567,P=0.003<0.05)。结论妊娠期甲状腺功能减退孕妇妊娠早期、中期的血清铁蛋白水平与甲状腺功能指标存在相关性,可为临床治疗提供重要的参考依据。

Objective To discuss the correlation between serum ferritin level and thyroid function index in women with hypothyroidism during pregnancy.Methods 280 women with hypothyroidism in pregnancy who had regular obstetric examinations were selected as the observation group,with 98 cases in early pregnancy,96 cases in middle pregnancy and 86 cases in late pregnancy.Meanwhile,280 pregnant women with healthy physical examination during the same period were selected as the control group,with 98 cases in early stage of pregnancy,96 cases in middle stage of pregnancy,and 86 cases in late stage of pregnancy.All patients underwent serum ferritin as well as thyroid hormone[free thyroxine(FT4),thyroid stimulating hormone(TSH)]testing.The serum ferritin levels in the early,middle and late stages of pregnancy in the two groups were compared,and the correlation between the serum ferritin levels and thyroid function index in the observation group was analyzed.Results The serum ferritin levels of pregnant women in the early,middle and late stages of pregnancy in both groups showed a decreasing trend;the serum ferritin levels were(14.02±6.40),(11.89±3.23)and(8.77±1.90)μg/L in the early,middle and late pregnant women in the observation group,which were lower than(54.55±6.97),(17.26±2.78)and(11.07±1.56)μg/L in the control group;the differences were all statistically significant(P<0.05).Pearson analysis showed that the serum ferritin level in the observation group was positively correlated with FT4 level in the early,middle stages of pregnancy(r=0.304,0.391;P=0.038,0.047<0.05),while the serum ferritin level was negatively correlated with TSH level in the middle stages of pregnancy(r=-0.567,P=0.003<0.05).Conclusion There is a correlation between serum ferritin levels and hypothyroidism in patients with hypothyroidism during pregnancy in the early and middle stages of pregnancy,which can provide an important reference for clinical treatment.