苯巴比妥钠联合地西泮治疗热性惊厥患儿的效果及安全性

Effect and safety of phenobarbital sodium combined with diazepam in the treatment of children with febrile convulsion

目的 探讨苯巴比妥钠联合地西泮治疗热性惊厥患儿的效果及安全性。方法 选择2018年10月至2020年10月本院收治的80例热性惊厥患儿作为研究对象,采用随机分配法将其分为对照组和观察组,各40例。对照组采用地西泮治疗,观察组在对照组基础上采用苯巴比妥钠治疗。比较两组的体温、脑神经因子水平、Ashworth痉挛等级及并发症发生情况。结果 治疗24 h后,观察组的体温和神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)及中枢神经特异性蛋白(S-100β)水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗24 h后,观察组Ashworth痉挛等级优于对照组,0级占比高于对照组,差异具有统计学意义(P<0.05)。观察组的并发症总发生率低于对照组,差异具有统计学意义(P<0.05)。结论 苯巴比妥钠联合地西泮治疗热性惊厥患儿能迅速降低体温,解除痉挛,调节脑神经因子水平,降低并发症发生风险。

Objective To investigate the effect and safety of phenobarbital sodium combined with diazepam in the treatment of children with febrile convulsion.Methods Eighty children with febrile convulsion admitted in our hospital from October 2018 to October 2020 were selected as the research objects and divided into control group and observation group according to random distribution method,with 40 cases in each group.The control group was treated with diazepam,and the observation group was treated with phenobarbital sodium on the basis of the control group.The body temperature,brain nerve factors levels,Ashworth spasm grade and complications were compared between the two groups.Results After 24 h of treatment,the body temperature and the levels of neuron-specific enolase(NSE),brain-derived neurotrophic factor(BDNF)and central nerve specific protein(S-100β)in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,the grade of Ashworth spasm in the observation group was better than that in the control group,the proportion of grade 0 was higher than that in the control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Phenobarbital sodium combined with diazepam in the treatment of children with febrile convulsion can quickly decrease body temperature,relieve spasm,regulate brain nerve factors levels,and reduce the risk of complications.