猫须草治疗慢性肾脏病用药规律

Analysis of Medication Law of Maoxucao(Spicate Clerodendranthus Herb) in Treating Chronic Renal Disease

目的:基于古今医案云平台分析傣药猫须草治疗慢性肾脏病的用药规律。方法:收集含猫须草治疗慢性肾脏病的病历资料,从门诊系统中摘录符合纳入标准的医案信息并建立处方数据库,运用系统集成的统计分析、聚类分析、复杂网络分析等方法分析病案的组方用药频次、药物配伍关系等。结果:最终纳入149个病案,分析得出常用配伍较高的有白术、牛膝、杜仲等,药性以平、温、微寒为主,药味以甘、苦、酸居多,主要归肝、脾、肾经,药物功效以补肝肾、强筋骨为法;药物聚类分析得出3个聚类分析结果;复杂网络分析获得常用配伍的核心方药是白术、牛膝、杜仲、太子参、鬼箭羽、白芍、牡丹皮、麦冬、墨旱莲;进一步分析“方-药”和“症-药”得出治疗泡沫尿、水肿、乏力等症状的药物配伍规律。结论:猫须草在治疗慢性肾脏病的临床应用中侧重于辨证施治,注意多种药物的联合使用,扶正与祛邪共施。

Objective:Based on the ancient and modern medical record cloud platform,to analyze the medication rule of Dai medicine Maoxucao in treatment of chronic kidney disease.Methods:Collect the medical record data of chronic kidney disease treated with felwort,extract the medical record information that meets the inclusion criteria from the outpatient system,and establish the prescription database.Use the methods of statistical analysis,cluster analysis,complex network analysis and other methods of system integration to analyze the frequency of prescription and drug compatibility of the medical record.Results:149 medical records were finally included,and the analysis indicates that the commonly used ingredients with high compatibility are Baizhu(atractylodes macrocephala),Niuxi(achyranthes bidentata),Duzhong(eucommia ulmoides oliv),etc.The drug properties are mainly mild,warm,and slightly cold,and the taste are mainly sweet,bitter,and sour,most of which attributed to the Liver,Spleen and Kidney meridians.The drug efficacy is to strengthen the Liver and Kidney and to strengthen the muscles and bones.Three results of drug cluster analysis were obtained;The core prescription drugs commonly used for compatibility obtained from complex network analysis are Baizhu(atractylodes macrocephala),Niuxi(achyranthes bidentata),Duzhong(eucommia ulmoides oliv),Taizishen(radix Pseudostellariae),Guijianyu(ramuli euonymi),Baishao(radix paeoniae alba),Mudanpi(peony bark),Maidong(ophiopogon japonicus)and Mohanlian(Eclipta);Further analysis of the relationship between"prescription and medicine"and"symptom and medicine"leads to the rule of drug compatibility for the treatment of foam urine,edema,fatigue and other symptoms.Conclusion:In the clinical application of spicate clerodendranthus herb in treating chronic kidney disease,we should focus on the treatment based on syndrome differentiation and pay attention to the combined use of multiple drugs so as to strengthen the Zheng Qi and remove the evil factors.