摘要
炎症性肠病(IBD)是一种慢性非特异性肠道炎症性疾病,发病机制不明。部分IBD患者对常规药物治疗反应不佳。目前认为哺乳动物雷帕霉素靶蛋白(mTOR)可通过PI3K/AKT/mTOR、TLR4/MAPK/mTOR和AMPK/mTOR等多种机制影响肠道自噬和炎症过程,从而影响疾病的发生发展过程。通过靶向mTOR信号通路可为IBD的治疗提供新的可能。本文就mTOR信号通路在IBD中的作用机制以及靶向mTOR信号通路治疗IBD进行总结。
Inflammatory bowel disease(IBD)is a chronic non-specific intestinal inflammatory disease with unknown pathogenesis,and some IBD patients do not respond well to conventional medications.Currently,mammalian target of rapamycin(mTOR)can affect intestinal autophagy and inflammation progress through various mechanisms such as PI3K/AKT/mTOR,TLR4/MAPK/mTOR and AMPK/mTOR.By this way,mTOR can play a significant role in its pathogenesis.Targeting mTOR signaling pathway provides new therapeutic options for IBD.In this article,the mechanisms of mTOR signaling pathway in IBD and the targeted treatment of mTOR signaling pathway for IBD were summarized.
作者
张淇
向冰洁
郅敏
张敏
Zhang Qi;Xiang Bingjie;Zhi Min;Zhang Min(Department of Gastroenterology,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China)
出处
《中华炎性肠病杂志（中英文）》
2023年第1期81-85,共5页
Chinese Journal of Inflammatory Bowel Diseases
基金
中山大学临床医学研究5010计划项目(2014008)。
关键词
炎症性肠病
哺乳动物雷帕霉素靶蛋白
信号通路
治疗
Inflammatory bowel disease
Mammalian target of rapamycin
Signaling pathway
Treatment
