基于Web of Science数据库的糖尿病视网膜病变治疗研究的文献计量学分析

Bibliometric analysis of diabetic retinopathy therapy based on Web of Science database

目的了解糖尿病视网膜病变(DR)治疗的研究趋势、热点与前沿。方法以美国科学情报研究所Webof Science核心数据集为数据源,检索DR治疗相关文献,检索时间为2017至2021年。采用文献计量学分析软件VOSviewer和CiteSpace对高频主题词、爆发词突现、共被引网络进行可视化分析。结果共检索到DR治疗相关文献3845篇,其中2017年至2021年发文量分别为633、651、708、893、960篇,呈逐年上升趋势。中国学者发文量最多,其次为美国。中国国家自然科学基金资助文章数位居第三。确定高频主题词47个,呈现类别的显著聚类现象,分别为DR治疗方法、DR相关机制、DR诊断相关。氧化应激、糖尿病黄斑水肿(DME)、2型糖尿病相关、光相干断层扫描、深度学习为持续研究热点且不断出现的新关键词。突变强度排名前11位的爆发词中,玻璃体腔注射贝伐单抗、血管内皮生长因子(VEGF)、脉络膜新生血管、抑制、受体的突现强度均>10。高被引频次参考文献呈现显著聚类现象,分别为DME治疗相关临床研究、DR研究的综述性总结、抗VEGF药物治疗相关临床研究。结论DR治疗相关研究文献呈增长趋势;DR发病机制的具体治疗方法依旧是研究热点,制定减轻黄斑水肿与糖尿病其他并发症的综合防治的治疗策略,应用光相干断层扫描、深度学习等技术提高DR的诊治效率,发展改进药物递送系统提高DR治疗的靶向性,寻找特异性治疗新靶点是未来研究的趋势所在。

Objective To analyze the trend,hotspots and frontiers of diabetic retinopathy(DR)therapy by bibliometric method.Methods Data were taken from the Web of Science website of Science Citation Index.Articles from 2017 to 2021,which were related to the therapy of diabetic retinopathy(DR),were included.The bibliometric analysis softwares,VOSviewer and CiteSpace were used to generate and analyze visual representations of the complex data input,including high-frequency keywords,keywords with the strongest citation bursts and co-occurrence networks of keywords.Results A total of 3,845 articles were included.The amounts of papers published from 2017 to 2021 is 633,651,708,893,and 960 respectively,increasing over years.Chinese scholars published the most articles,followed by the United States.The number of articles funded by the National Natural Science Foundation of China ranks third.There were 47 high-frequency keywords clustered into DR treatment,pathogenesis of DR,diagnosis of DR,Oxidative stress,diabetic macular edema(DME),type 2 diabetes,optical coherence tomography and deep learning.Those keywords were research hotspots and new keywords were constantly emerging.Among the top 11 burst words,the burst values of“intravitreal bevacizumab”,“vascular endothelial growth factor(VEGF)”,“choroidal neovascularization”,“inhibition”,and“receptors”were all over 10.Highly cited references showed a significant clustering tendency,which were treatment of DME,review of DR,clinical research of anti-VEGF drug therapy.Conclusions The amount of paper related to DR therapy is on the rise;the specific treatment methods for the pathogenesis of DR are constantly research hotspots.In addition,formulating treatment strategies to reduce macular edema and other complications of diabetes,applying optical coherence tomography,deep learning and other technologies to improve the efficiency of DR diagnosis and treatment,improve targeted drug delivery systems,and finding new target points were research frontiers。