肠道菌群失调与骨关节炎关系的研究进展

Research progress on the relationship between gut microbiota dysbiosis and osteoarthritis

目的综述肠道菌群失调与骨关节炎(osteoarthritis,OA)关系的研究进展,重点总结肠道菌群失调促进OA发展的可能机制,进一步提出新的治疗方向。方法查询国内外关于肠道菌群失调与OA关系的研究文献,总结前者在OA发生发展中的作用,探讨OA治疗新思路。结果肠道菌群失调主要通过三方面促进OA发展,一是通过破坏肠道通透性并引起全身低度炎症,从而加重OA;二是经由代谢综合征促进OA发展;三是通过调节微量元素的运输及代谢参与OA发展。研究表明,通过服用益生菌、益生元以及进行粪便微生物群移植等方式来改善肠道菌群失调,可减轻全身炎症、调节代谢平衡,进而治疗OA。结论肠道菌群失调与OA发展联系紧密,改善肠道菌群失调可作为OA治疗的重要思路。

Objective To introduce the research progress on the relationship between gut microbiota dysbiosis and osteoarthritis(OA),focus on the possible mechanism of gut microbiota dysbiosis promoting OA,and propose a new therapeutic direction.Methods The domestic and foreign research literature on the relationship between gut microbiota dysbiosis and OA was reviewed.The role of the former in the occurrence and development of OA and the new ideas for the treatment of OA were summarized.Results The gut microbiota dysbiosis promotes the development of OA mainly in three aspects.First,the gut microbiota dysbiosis destroys intestinal permeability and causes low-grade inflammation,which aggravate OA.Secondly,the gut microbiota dysbiosis promotes the development of OA through metabolic syndrome.Thirdly,the gut microbiota dysbiosis is involved in the development of OA by regulating the metabolism and transport of trace elements.Studies have shown that improving gut microbiota dysbiosis by taking probiotics and transplanting fecal microbiota can reduce systemic inflammation and regulate metabolic balance,thus treating OA.Conclusion Gut microbiota dysbiosis is closely related to the development of OA,and improving gut microbiota dysbiosis can be an important idea for OA treatment.