早期特发性全面性癫痫大脑皮质厚度脑图谱的建立研究

Establishment of the cerebral cortex thickness atlas in early Idiopathic Generalized Epilepsy

目的 采用大脑磁共振T1图像及先进的图像分析软件,构建初次就诊的特发性全面性癫痫(Idiopathic generalized epilepsy,IGE)大脑皮质厚度脑图谱。方法 选取2020年1月1日-2021年12月31日于寿光市人民医院就诊的27例初诊为IGE患者和29名正常对照组获得高分辨率三维T1图像。利用Freesurfer软件的定位识别计算系统,计算每个脑区皮质厚度的具体数值,利用图像分析软件,将皮质厚度数值制作成脑图谱。利用两样本t检验,形成差异脑图谱,分析IGE患者同正常人皮质厚度的差异。运用配对t检验进行对两组数据进行组内比较,探讨皮质厚度偏侧性的改变。结果 IGE脑图谱中皮质厚度较厚的脑区为右左侧颞极、右左侧内嗅皮层、右侧前扣带回头部、右左侧岛叶、右左侧颞中回、右侧颞下回、左侧前扣带回头部、左侧前扣带回尾部、左侧颞下回、左右侧梭状回、左侧额极;皮质厚度较薄的区域为右左侧距状旁回、右左侧楔叶、左右侧舌回、左右侧中央后回、左侧枕外侧回、右左侧顶上回;与正常人脑皮质厚度脑图谱比较,皮质厚度分布规律大致相仿;与正常人比较,IGE大脑皮质厚度发生改变的区域为双侧额上回、双侧中央后回、双侧中央前回、双侧舌回、左侧楔叶、双侧内嗅皮质及颞极。IGE左右大脑半球皮质厚度存在偏侧性的脑区为前扣带回尾部、楔叶、顶下回、枕外侧回、中央后回、前扣带回头部、缘上回;与正常人相比,IGE大脑皮质厚度存在偏侧性的脑区的数量减少。结论 本研究从早期特发性全面性癫痫大脑皮层厚度脑图谱中发现其分布规律及偏侧性,为之后脑科学的研究提供影像结构基础。

Objective To construct a map of cerebral cortex thickness in Idiopathic Generalized Epilepsy(IGE)diagnosed at the first visit,using T1-weighted brain magnetic resonance imaging and advanced image analysis software.Methods High-resolution three-dimensional T1 images were obtained from 27 IGE patients diagnosed at the first visit and 29 normal controls in Shouguang People's Hospital from January 1,2022 to December 31,2021.The location recognition calculation system of the Freesurfer software was used to calculate the values of cortical thickness in each brain region,and the cortical thickness values were transformed into a brain atlas using the image analysis software.A differential brain atlas was generated using the two-sample t-test to analyze the difference in cortical thickness between IGE patients and normal controls.Paired t-test was used for within-group comparison to explore changes of cortical thickness laterality.Results In the IGE brain atlas,the brain regions with higher cortical thickness were the right left temporal pole,the right left entorhinal cortex,the head of the right anterior cingulate gyrus,the right and left insular lobe,the right and left middle temporal gyrus,the right inferior temporal gyrus,the head of the left anterior cingulate gyrus,the left tail of the anterior cingulate gyrus,the left inferior temporal gyrus,the left and right fusiform gyrus,and the left frontal pole.The areas with lower cortical thickness were the right and left paracalcaric gyrus,the right and left cuneiform lobe,the left and right lingual gyrus,the left and right posterior central gyrus,the left lateral occipital gyrus,and the right and left superior parietal gyrus.The distribution of cortical thickness of the IGE group was comparable to the cortical thickness atlas of the normal control.Compared with normal control,the areas with changes of cortical thickness in the IGE group were bilateral superior frontal gyrus,bilateral posterior central gyrus,bilateral anterior central gyri,bilateral lingual gyri,left cuneiform lobe,bilateral entorhinal cortex and temporal pole.The brain areas with laterality of cortical thickness between hemispheres in the IGE group were the tail of anterior cingulate gyrus,cuneiform lobe,inferior parietal gyrus,lateral occipital gyrus,posterior central gyrus,head of anterior cingulate gyrus,and superior marginal gyrus.Compared with normal control,the IGE group has decreased number of brain regions with laterality of cortical thickness.Conclusion The present study revealed the distribution and laterality of cerebral cortical thickness map in early idiopathic generalized epilepsy,which provides imaging structural basis for brain research in the future.