肌少症与认知功能障碍相关性的系统评价

Correlation between sarcopenia and cognitive dysfunction: a systematic review

目的 系统评价肌少症与认知功能障碍的相关性。方法 计算机检索CNKI、WanFang Data、PubMed、EMbase和Web of Science数据库,搜集肌少症与认知功能障碍相关性的研究,检索时限均从建库至2022年6月15日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3和Stata 14.0软件进行Meta分析。结果 共纳入13个研究,包括19 262例研究对象。Meta分析结果显示:肌少症与认知功能障碍相关[OR=1.82,95%CI(1.58,2.11),P<0.01]。亚组分析结果显示,亚洲、欧洲地区肌少症与认知功能障碍相关,但美洲地区两者之间无统计学相关性。结论 当前证据显示,肌少症与认知功能障碍之间存在相关性,但不同地域可能有差异。受纳入研究数量和质量限制,上述结论尚待更多高质量研究予以验证。

Objective To systematically review the correlation between sarcopenia and cognitive dysfunction.Methods CNKI,WanFang Data,PubMed,EMbase and Web of Science databases were electronically searched to collect studies on the correlation between sarcopenia and cognitive dysfunction from inception to June 15,2022.Two reviewers independently screened the literature,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed by using RevMan 5.3 and Stata 14.0 software.ResultsA total of 13 studies involving 19262 subjects were included.Meta-analysis showed that the cognitive dysfunction was significantly associated with sarcopenia(OR-1.82,95%CI 1.58 to 2.11,P<0.01).The results of subgroup analysis showed that the cognitive dysfunction was significantly associated with sarcopenia in Asia and Europe.However,the incidence of cognitive dysfunction in the Americas was not significantly associated with sarcopenia.Conclusion Current evidence shows that there is a significant correlation between sarcopenia and cognitive dysfunction,but there may be differences in different regions.Due to the limited quality and quantity of the included studies,more high quality studies are needed to verify the above conclusion.