P2X_(3)受体在病理性疼痛中的研究进展

Research Progress of P2X_(3)Receptor in Pathological Pain

病理性疼痛在临床很难完全治愈,严重影响病患的身心健康.由于病理性疼痛机制复杂,探索新的临床治疗策略是研究挑战.嘌呤能离子通道受体3(P2X_(3)R)属于嘌呤能受体家族中的一员,在神经系统中主要分布于初级伤害性传入神经元.在伤害性刺激作用下,P2X_(3)R通道开放,阳离子大量内流,通过激活下游相关信号通路参与感觉信息传递,导致神经系统敏化,促进病理性疼痛的发生发展.近些年以P2X_(3)R为靶点缓解病理性疼痛受到广泛关注,就P2X_(3)R在病理性疼痛中的作用进行综述.

Pathologic pain is difficult to be completely cured clinically and seriously affects the physical and mental health of patients.Due to the complex mechanism of pathologic pain,it is a research challenge to explore new clinical treatment strategies.Purinergic ion channel receptor 3(P2X_(3)R),a member of the purinergic receptor family,is mainly distributed in primary nociceptive afferent neurons in the nervous system.Under the action of nociceptive stimulation,P2X_(3)R channel opens and a large number of cations flow in,which participate in sensory information transmission by activating downstream related signaling pathways,leading to nervous system sensitization,and further promoting the occurrence and development of pathologic pain.Targeting P2X_(3)R for relieving pathologic pain has attracted extensive attention in recent years.This article briefly reviews the role of P2X_(3)receptor in pathologic pain.