基于“脾主肌肉”理论探讨慢性阻塞性肺疾病合并肌少症的病因病机

Exploring the Pathogenesis of Chronic Obstructive Pulmonary Disease Complicated with Sarcopenia Based on the Theory of"Pi Governing Muscles"

慢性阻塞性肺疾病(COPD)是一种慢性呼吸系统疾病,伴有许多呼吸系统外并发症。肌少症是COPD的常见合并症,是一种全身性疾病,临床表现为肌力下降、耐力下降、肌肉萎缩等症状,是COPD预后不良的独立危险因素。COPD合并肌少症与中医学的痿证较为相似,与肺、脾、肾、心等脏腑的虚损密切相关。基于中医学“脾主肌肉”理论,结合中医文献及相关现代医学研究,笔者通过论述COPD合并肌少症的中西医研究进展,探讨COPD合并肌少症的病因病机。

Chronic obstructive pulmonary disease(COPD)is a chronic respiratory disease with many extra-respiratory complications.As a common complication of COPD,sarcopenia is a systemic disease with clinical manifestations such as decreased muscle strength,decreased physical endurance,and muscle atrophy.It is an independent risk factor for poor prognosis of COPD.COPD complicated sarcopenia is very similar to the atrophy syndrome in Chinese medicine,and is closely related to the asthenic disease in organs such as the Fei,Pi,Shen,Xin,etc.Based on the theory of"Pi governing muscles"in Chinese medicine and reference to Chinese medicine literature and related modern medical research,the author discusses the pathogenesis of COPD complicated sarcopenia by discussing the research progress of Chinese and Western medicine in COPD complicated sarcopenia.