基于Web of Science数据库对肝脏类器官相关文献的计量学分析

Bibliometric Analysis of Literature Related to Liver Organoids Based on the Web of Science Database

目的通过文献计量学分析肝脏类器官的相关研究文献,了解国内外肝脏类器官的研究现状。方法计算机检索2010-2021年Web of Science核心合集(WOSCC)中发表的肝脏类器官相关文献,分析文献的发文量、被引频次、国家与机构、来源期刊,并用VOSviewer 1.6.15软件从文献标题和摘要中提取关键词进行可视化分析。结果共纳入文献499篇,发文量和被引频次总体呈增长趋势,发表相关文献最多的期刊为SCIENTIFIC REPORTS,其次为HEPATOLOGY;美国是肝脏类器官相关文献的主要产出国家,我国文献产出量排名第2;中国科学院为发表相关文章最多的国内机构;该领域的主要研究热点包括组织结构、肝脏功能、疾病建模、药物筛选、通路、基因、患者、肿瘤类器官等。结论2010-2021年发表的肝脏类器官文献总体呈增长趋势,肝脏类器官作为与人类高度相关的体外研究模型,具有巨大的临床应用潜力,研究人员应投入更多的研究,深化合作,从临床角度发现问题,在肝脏类器官领域寻找解决方案,为肝脏类器官的基础研究和临床应用奠定基础。

Objective To analyze the related research literature of liver organoids by bibliometrics method,and to understand the research status of liver organoids at home and abroad.Methods A computer-based retrieval of liver organoids-related literature published in the Web of Science Core Collection(WOSCC)from 2010 to 2021 was conducted.The number of publications,citations,countries and institutions,and source journals were analyzed.VOSviewer 1.6.15 software was used to extract keywords from literature titles and abstracts for visual analysis.Results A total of 499 articles were included,and the number of publications and citations showed an overall increasing trend.The journal with the most relevant literature was SCIENTIFIC REPORTS,followed by HEPATOLOGY.The United States was the main output country of liver organ-related literature,and China ranks second in literature output.The Chinese Academy of Sciences is the domestic institution that publishes the most relevant articles;the main research hotspots in this field include tissue structure,liver function,disease modeling,drug screening,pathways,genes,patients,tumor-like organs,etc.Conclusion The literature on liver organoids published from 2010 to 2021 is generally on the rise.As an in vitro research model highly related to humans,liver organoids have great potential for clinical application.Researchers should invest more research,deepen cooperation,find problems from a clinical perspective,and find solutions in the field of liver organoids,laying a foundation for basic research and clinical application of liver organoids.