血清细胞质胸苷激酶对消化道肿瘤诊断价值分析

Analysis of Diagnostic Value of Serum Thymidine Kinase 1 in Gastrointestinal Cancer

目的探讨血清细胞质胸苷激酶(TK1)对消化道肿瘤的诊断及预防价值。方法选择2018年3月-2019年12月在诸城市人民医院行消化道手术的238例消化道病变患者。将消化道早期肿瘤患者77例设为早期组,消化道中晚期肿瘤患者85例设为中晚期组,另选消化道良性疾病患者76例设为对照组。采用免疫印迹增强化学发光法检测所有入选对象血清TK1含量。比较中晚期肿瘤组、早期组、良性组3组的TK1值,并分析肿瘤患者随访时复发情况。结果中晚期组与早期组患者TK1水平高于对照组,差异有统计学意义(P<0.05);事后分析表明,中晚期组与早期组TK1水平比较,差异无统计学意义(P>0.05);中晚期组与早期组TK1水平均高于良性组,差异有统计学意义(P<0.05);同时,术后中晚期组TK1含量高于早期组(P<0.05);血清TK1与血清癌胚抗原(CEA)的表达呈正相关(r=0.312,P=0.028);ROC曲线结果表明,血清TK1用于诊断消化道肿瘤的曲线下面积是0.746。结论TK1的检测对于消化道肿瘤的早期筛查及预测术后复发风险具有重要意义,用于诊断消化道肿瘤的敏感性较高。

Objective To investigate the value of serum thymidine kinase 1(TK1)in the diagnosis and prevention of gastrointestinal tumors.Methods A total of 238 patients with gastrointestinal tumors who underwent digestive tract surgery in Zhucheng People's Hospital from March 2018 to December 2019 were selected.77 patients with early gastrointestinal cancer were set as early group,85 patients with advanced gastrointestinal cancer were set as middle-late group,and 76 patients with benign gastrointestinal diseases were selected as control group.The serum TK1 content of all subjects was detected by immunoblotting enhanced chemiluminescence.The TK1 values of the three groups of advanced tumor group,early group and benign group were compared,and the recurrence of tumor patients during follow-up was analyzed.Results The level of TK1 in the middle-late group and the early group was higher than that in the control group,and the difference was statistically significant(P<0.05).Post-hoc analysis showed that there was no significant difference in TK1 level between the middle-late group and the early group(P>0.05).The level of TK1 in the middle-late group and the early group was higher than that in the benign group,and the difference was statistically significant(P<0.05).At the same time,the content of TK1 in the middle and late group was higher than that in the early group(P<0.05).Serum TK1 was positively correlated with serum carcinoembryonic antigen(CEA)expression(r=0.312,P=0.028).The ROC curve results showed that the area under the curve of serum TK1 for the diagnosis of gastrointestinal tumors was 0.746.Conclusion The detection of TK1 is of great significance for the early screening of gastrointestinal tumors and the prediction of the risk of postoperative recurrence.