APOE基因多态性与精神分裂症的相关性研究

Study on the Correlation Between APOE Gene Polymorphism and Schizophrenia

目的研究精神分裂症患者载脂蛋白E基因(APOE)多态性的分布情况并探究其多态性对精神分裂症的影响。方法选取中山市第三人民医院2019年7月-2020年7月收治的123例精神分裂症患者作为试验组,同期52例正常体检成年人为对照组,检测所有受检者的APOE基因型,比较两组受检者APOE基因6种基因型和3种表现型的分布情况并进行研究。结果两组APOE基因型和表现型分别比较,差异无统计学意义(P>0.05);两组不同APOE基因型和表现型的分布比较,差异有统计学意义(P<0.05);试验组APOE基因型多态性分布情况为ε2/ε3型7例(5.69%)、ε3/ε3型92例(74.80%)、ε2/ε4型3例(2.44%)、ε3/ε4型21例(17.07%)、ε2/ε2和ε4/ε4型均为0例;表现型:E2型7例(5.69%)、E3型95例(77.24%)、E4型21例(17.07%);ApoE基因型及表现型在不同性别患者间分布比较,差异无统计学意义(P>0.05)。结论APOE基因多态性不是精神分裂症的特定危险因素,其多态性分布与患者性别无关。

Objective To study the distribution of apolipoprotein E gene(APOE)polymorphism in patients with schizophrenia and to explore the effect of its polymorphism on schizophrenia.Methods A total of 123 patients with schizophrenia admitted to the Zhongshan Third People's Hospital from July 2019 to July 2020 were selected as the experimental group,and 52 healthy adults were selected as the control group during the same period.The APOE genotypes of all subjects were detected,and the distribution of 6 genotypes and 3 phenotypes of APOE gene were compared between the two groups.Results There was no significant difference in ApoE genotype and phenotype between the experimental group and the control group(P>0.05).There were significant differences in the distribution of different APOE genotypes and phenotypes between the two groups(P<0.05).The distribution of APOE genotype polymorphism in the experimental group was 7 cases(5.69%)ofε2/ε3,92 cases(74.80%)ofε3/ε3,3 cases(2.44%)ofε2/ε4,21 cases(17.07%)ofε3/ε4,0 case ofε2/ε2 andε4/ε4;there were 7 cases(5.69%)of E2 type,95 cases(77.24%)of E3 type and 21 cases(17.07%)of E4 type.There was no significant difference in the distribution of ApoE genotypes and phenotypes between patients of different genders(P>0.05).Conclusion APOE gene polymorphism is not a specific risk factor for schizophrenia,and its polymorphism distribution is not related to gender.