难治性癫痫发病机制的研究进展

Research Progress in Pathogenesis of Refractory Epilepsy

癫痫是一种常见的临床综合征,其反复发作的特性严重影响患者生活质量,增加患者的死亡率及致残率。难治性癫痫(refractory epilepsy,RE)的治疗是目前临床所面临的主要问题,研究其发病机制是开发新治疗策略的重要基础。但其发病机制错综复杂,迄今为止,学者们提出了多种关于RE发病机制的假说,如药物转运蛋白假说、神经网络假说、药物靶点假说、基因突变假说、疾病自身严重性假说和药代动力学假说等。这些假说从不同方面阐述了RE的发病机制,但仍各有许多不足之处和争议。文章对RE发病机制的相关研究进行综述。

Epilepsy is a common clinical syndrome,and its recurrent seizures seriously affect the quality of life of patients and increase the rates of mortality and disability.The treatment of refractory epilepsy(RE)is currently a major clinical problem,and the study on its pathogenesis is an important basis for developing new treatment strategies.Nevertheless,the pathogenesis of RE is a complex problem.To date,scholars have proposed a variety of hypotheses about the pathogenesis of RE,such as drug transporter hypothesis,neural network hypothesis,drug target hypothesis,gene variant hypothesis,intrinsic severity hypothesis,and pharmacokinetic hypothesis.These hypotheses have explained the pathogenesis of RE from different perspectives,but there are still many shortcomings and controversies.This article reviews the related research on the pathogenesis of RE.