静磁场辅助β-环糊精包埋广藿香精油

β-Cyclodextrin Encapsulated Pogostemon cablin Oil with the Assistance of Static Magnetic Field

为探究静磁场对挥发性药物包埋性能的影响,以β-环糊精为包埋壁材,广藿香精油为芯材,在0、3、6和10 mT静磁场环境下,测定β-环糊精与广藿香精油在不同包合参数下包埋率的变化规律。结果表明,随壁材质量分数、芯材质量分数、壁芯比、温度、处理时间和转速的增加,广藿香精油的包埋率先增加后下降。相同包合条件下,与对照相比,随静磁场强度增加,广藿香精油包埋率显著增大(P<0.05)。与对照相比,3、6和10 mT静磁场下,质量分数为30%的β-环糊精壁材和质量分数为80%的广藿香精油芯材,壁芯比3:1,温度45℃,200 r/min下处理2 h,广藿香精油包埋率分别增大4.46%、8.80%和13.01%,磁场环境有效提升了广藿香精油包合物的包埋性能,为促进挥发性药物的包埋提供了一种新的参考方法。

In order to explore the effect of static magnetic field on the embedding performance of volatile drugs,theβ-cyclodextrin and the Pogostemoncablin oil were used as embedded wall material and core material.The embedding rate ofβ-cyclodextrin and Pogostemoncablin oil under different binding parameters were analyzed at 0,3,6 and 10 mT static magnetic field.The results showed that the embedding rate of Pogostemoncablin oil increased firstly and then decreased with the increase of wall material mass fraction,core material mass fraction,wall core ratio,temperature,treatment time and rotational speed.Under the same inclusion conditions,compared with the control,the embedding rate of Pogostemoncablin oil increased significantly with the increase of static magnetic field intensity(P<0.05).Compared with the control,under 3,6 and 10 mT static magnetic field,the embedding rate of Pogostemoncablin oil increased by 4.46%,8.80%and 13.01%respectively when wall material ofβ-cyclodextrin with a mass fraction of 30%and the core material of Pogostemoncablin oil with a mass fraction of 80%were treated at 45℃and 200 r/min for 2 h with a wall core ratio of 3:1.Static magnetic field enhanced the entrapment performance of the Pogostemoncablin oil inclusion compound,and this study provides a new reference method for promoting the embedding of volatile drugs.