松弛素与盆腔器官脱垂的关联及潜在机制研究现状

Current status of research on association between relaxin and pelvic organ prolapse and its potential mechanisms

盆腔器官脱垂(POP)是盆底功能障碍性疾病的最常见类型之一,对中老年妇女的身心健康造成了很大的危害。随着老龄化程度的加深,POP的发病率也逐年增加,给患者及医疗系统带来了较重的负担。然而关于POP的发病机制,目前还没有得出明确的结论。松弛素(RLX)是类胰岛素样的妊娠相关激素之一。既往有许多研究发现RLX不仅与POP发生风险增加存在显著的关联,在胶原沉积与降解、炎性细胞浸润、细胞凋亡、血管扩张、基因表达等过程中也发挥了至关重要的作用。本文结合国内外最新研究进展对RLX与POP的关联和潜在机制进行了综述,期待为POP的发病机制与疾病预防提供新的思路。

Pelvic organ prolapse(POP)is one of the most common types of pelvic floor dysfunction and poses a great risk to the physical and mental health of middle-aged and elderly women.With the increasing aging,the incidence of POP is also increasing year by year,which brings a heavy burden to patients and the healthcare system.However,no clear conclusion has been reached on the pathogenesis of POP.Relaxin(RLX)is one of the insulin-like pregnancy-related hormones.Many previous studies have found that RLX is not only significantly associated with an increased risk of POP,but also plays a crucial role in collagen deposition and degradation,inflammatory cell infiltration,apoptosis,vasodilation,and gene expression.Based on the latest research progress at home and abroad,this paper reviews the association and potential mechanism of RLX and POP,hoping to provide new ideas for the pathogenesis and disease prevention of POP.