中国适龄儿童水痘疫苗第2剂接种率的荟萃分析

Meta-analysis of the second dose of varicella vaccine in eligible Chinese children

目的评估我国适龄儿童水痘减毒活疫苗(varicella attenuated live vaccine, VarV)第2剂(VarV 2)接种率水平。方法检索中国知网、中国生物医学文献数据库、维普、PubMed和Web of Science电子数据库从2013年1月至2022年5月发表的VarV 2接种率相关文献, 使用Stata 15.0软件对VarV 2接种率进行荟萃分析。结果共检索到3 352篇文献, 其中19篇文献纳入荟萃分析。汇总结果显示, 我国适龄儿童VarV 2接种率为55.3%(95%置信区间:48.4%~62.2%, I^(2)=100%);本地儿童VarV 2接种率高于外地儿童, 不同性别儿童VarV 2接种率差异不大。敏感性分析发现VarV 2接种率介于53.5%~57.1%之间, 发表偏倚结果为阴性。结论目前我国VarV 2接种率处于较低水平, 建议适时推行VarV两剂接种策略, 已实施两剂接种策略的省份采取针对性措施以提高接种覆盖率。

Objective To evaluate the vaccination rate of the varicella attenuated live vaccine(VarV)second dose(VarV 2)among eligible children in China.Methods A search was performed for VarV 2 vaccination rate related studies published in CNKI,China Biology Medicine,VIP,PubMed and Web of Science electronic databases from January 2013 to May 2022.Meta-analysis of VarV 2 vaccination rate was performed using Stata 15.0 software.Results A total of 3352 literatures were retrieved,of which 19 were included in this Meta-analysis.The pooled results showed that the VarV 2 vaccination rate of eligible children in China was 55.3%(95%confidence interval:48.4%-62.2%,I^(2)=100%).The VarV 2 vaccination rate of local children was higher than that of non-local children,and the VarV 2 vaccination rates varied little among children of different sexes.Sensitivity analysis demonstrated that the VarV 2 vaccination rate ranged from 53.5%to 57.1%,and the results of publication bias were negative.Conclusion The VarV 2 vaccination rate in China is at a low level at present.It is recommended to implement the VarV two-dose vaccination strategy in a timely manner.Provinces that have implemented the two-dose vaccination strategy should take targeted measures to improve the vaccination coverage.