幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)

Chinese Expert Consensus on Juvenile Idiopathic Arthritis⁃associated Uveitis(2023)

幼年特发性关节炎(juvenile idiopathic arthritis,JIA)是儿童时期常见的风湿免疫性疾病。幼年特发性关节炎相关葡萄膜炎(juvenile idiopathic arthritis-associated uveitis,JIA-U)是JIA重要的关节外并发症,主要表现为隐匿起病的虹膜和睫状体前部非肉芽肿性炎症(虹膜睫状体炎),是造成儿童时期残疾和失明的重要原因之一。近年来,美国风湿病学会(American College of Rheumatology,ACR)及欧洲儿科风湿病学的单一枢纽和接入点(Single Hub and Access Point for Pediatric Rheumatology in Europe,SHARE)先后均发表了JIA-U的临床指南,但我国尚缺乏诊疗相关指导性文件。为进一步加强该病的临床认知和诊疗规范,中华医学会儿科学分会免疫学组、中国儿童风湿免疫病联盟、国家儿童健康与疾病临床研究中心风湿免疫联盟联合眼科专家共同制定了《幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)》,在疾病筛查、诊断、治疗等方面达成初步共识,以供临床参考。

Juvenile idiopathic arthritis(JIA)is a common chronic rheumatologic disease in childhood.JIA⁃associated uveitis(JIA⁃U),an important extra⁃articular complication of JIA,is one of the major causes of childhood disability and blindness.It is predominantly anterior,nongranulomatous inflammation affecting the iris and ciliary body(iridocyclitis)of insidious onset.Recently,American College of Rheumatology(ACR)and the Single Hub and Access Point for Pediatric Rheumatology in Europe(SHARE)have published clinical guidelines for JIA⁃U.There is no guideline of diagnosis and treatment of JIA⁃U in China.To promote the standardization of clinical understanding and treatment,the Subspecialty Group of Immunology of the Society of Pediatrics of Chinese Medical Association,Chinese Alliance of Pediatric Rheumatic and Immunologic Diseases,and National Clinical Research Center for Child Health and Disorders organized experts and scholars in related fields to discuss the is⁃sue and finally formed this consensus for clinicians􀆳reference.