2006和2014及2020年拉萨市1~14岁儿童乙肝流行病学调查及乙肝疫苗接种率分析

Epidemiological survey of hepatitis B and analysis of hepatitis B vaccine coverage rate among children aged 1-14 years in Lhasa in 2006,2014 and 2020

2006、2014和2020年,560、384和402名1~14岁儿童的HBsAg阳性率分别为4.5%、2.6%和2.5%,差异无统计学意义(P>0.05);2014年抗-HBs阳性率(57.8%)最高,2006年最低(34.1%)(P<0.05);2006年抗-HBc阳性率最高(15.7%),2014(7.8%)和2020年阳性率(5.7%)均有下降(P<0.001)。2006、2014和2020年拉萨市儿童乙肝疫苗首针及时率分别为7.7%(43/560)、50.3%(193/384)和94.8%(381/402),全程接种率分别为15.4%(86/560)、35.2%(135/384)和96.0%(386/402),均有逐渐升高的趋势(趋势χ^(2)值分别为718.63、589.59,均P<0.001)。

In 2006,2014 and 2020,the positive rates of HBsAg in 560,384 and 402 children aged 1 to 14 years were 4.5%,2.6%and 2.5%,respectively,with no statistically significant differences(P>0.05).The positive rate of anti-HBs was highest in 2014(57.8%)and lowest in 2006(34.1%)(P<0.05).The positive rate of anti-HBc was highest in 2006(15.7%),and decreased in 2014(7.8%)and 2020(5.7%)(P<0.001).The timely rate of the first dose of hepatitis B vaccine for children in Lhasa in 2006,2014 and 2020 was 7.7%(43/560),50.3%(193/384)and 94.8%(381/402),respectively.The overall vaccination rates were 15.4%(86/560),35.2%(135/384)and 96.0%(386/402),respectively,showing a trend of gradual increases(χ_(trend)^(2) values were 718.63 and 589.59,both P values<0.001).