Nrf2在脊髓损伤后铁死亡的研究进展

Research Progress of Nrf2 in Ferroptosis After Spinal Cord Injury

铁死亡是脊髓损伤(spinal cord injury,SCI)后神经元细胞损伤的重要病理机制之一,近几年受到国内外广泛关注,但并未取得突破性进展。目前,有研究发现氧化应激在SCI病理生理过程中发挥着重要作用。核因子E2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)因具有抗氧化应激作用并参与SCI后神经修复而成为研究热点,但其调控铁死亡发生发展的机制尚不明确。简要介绍了Nrf2的基础结构及其下游靶基因,总结了铁死亡的相关机制并探索了Nrf2在SCI治疗中的潜在作用,以期为进一步研究其与铁死亡在SCI发生发展中的关系和探索SCI治疗的新策略提供思路。

Ferroptosis is one of the important pathological mechanisms of neuronal cell injury after spinal cord injury(SCI).It has received widespread attention at home and abroad in recent years,but no effective breakthrough has been achieved.In recent years,it has been found that oxidative stress plays an important role in the pathophysiological process.Nuclear factor E2-related factor 2(Nrf2)has become a hot topic of research because of its anti-oxidative stress effect and involvement in neural repair after SCI,but its mechanism of regulating the development of ferroptosis is still unclear.In this paper,we briefly described the basic structure of Nrf2 and its downstream target genes,introduced the mechanism of ferroptosis and explored the potential role of Nrf2 in SCI treatment,and provided ideas for further study of its relationship with iron death in the development of SCI and explore new strategies for SCI treatment.