贝那普利联合硝苯地平缓释片对高血压患者肾素-血管紧张素-醛固酮系统的影响

Influence of Benazepril Combined with Nifedipine Sustained-Release Tablets on Renin-Angiotensin-Aldosterone System in Hypertension Patients

目的:观察贝那普利联合硝苯地平缓释片治疗高血压的效果,分析其对血清肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法:选取2020年4月—2022年3月于海淀区北太平庄社区卫生服务中心就诊的112例高血压患者为研究对象,按照随机数字表法分为对照组和观察组,各56例。对照组采用贝那普利治疗,观察组采用贝那普利联合硝苯地平缓释片治疗。比较两组收缩压(SBP)、舒张压(DBP)水平、血清RAAS指标水平、临床疗效及不良反应发生情况。结果:治疗前,两组患者SBP、DBP水平比较,差异无统计学意义(P>0.05);治疗2、4、8周后,观察组SBP、DBP水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组肾素、醛固酮、血管紧张素Ⅱ水平比较,差异无统计学意义(P>0.05);治疗后,观察组肾素、醛固酮、血管紧张素Ⅱ水平均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P=0.034)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:高血压患者采用贝那普利联合硝苯地平方案治疗效果确切,安全性较高。

Objective:To observe the effects of benazepril combined with nifedipine sustained-release tablets in the treatment of hypertension and analyze their influence on serum renin-angiotensin-aldosterone system(RAAS).Methods:A total of 112 patients with hypertension admitted to Haidian District Beitaipingzhuang Community Health Service Center from April 2020 to March 2022 were selected as the study subjects.According to the random number table method,the patients were divided into control group and observation group,with 56 cases in each group.The control group was treated with benazepril,and the observation group was treated with benazepril combined with nifedipine sustained-release tablets.The systolic blood pressure(SBP),diastolic blood pressure(DBP)level,serum RAAS index level,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in the levels of SBP and DBP between the two groups different(P>0.05).After 2,4 and 8 weeks of treatment,the SBP and DBP levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of renin,aldosterone and angiotensin Ⅱ between the two groups(P>0.05).After treatment,the levels of renin,aldosterone and angiotensin Ⅱ in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.034).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment scheme of benazepril combined with nifedipine is effective in hypertension patients,with high safety.